Anodic Production and Characterization of Biomimetic Oxide Layers on Grade 4 Titanium for Medical Applications

Biomaterials are the basis for the development of medicine because they allow safe contact with a living organism. The aim of this work was to produce innovative oxide layers with a microporous structure on the surface of commercially pure titanium Grade 4 (CpTi G4) and to characterize their propert...

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Bibliographic Details
Published in:Journal of functional biomaterials 2024-06, Vol.15 (7), p.180
Main Authors: Nowińska, Delfina, Osak, Patrycja, Maszybrocka, Joanna, Łosiewicz, Bożena
Format: Article
Language:English
Subjects:
Absorption spectroscopy
Ammonium
anodization
Anodizing
Biocompatibility
Biomaterials
Biomedical materials
Biomimetics
Bones
Chemical polishing
Drug carriers
Drug delivery
Drug delivery systems
Drug dosages
Electrochemistry
Electrolytes
Electropolishing
Ethylene glycol
Gentamicin
Medical innovations
Medicine
Oxidation
oxide layer
Pore size
Pores
porous titanium
Room temperature
Structural analysis
Surface roughness
Titanium
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Summary:Biomaterials are the basis for the development of medicine because they allow safe contact with a living organism. The aim of this work was to produce innovative oxide layers with a microporous structure on the surface of commercially pure titanium Grade 4 (CpTi G4) and to characterize their properties as drug carriers. The anodization of the CpTi G4 subjected to mechanical grinding and electrochemical polishing was carried out in a solution of 1M ethylene glycol with the addition of 40 g of ammonium fluoride at a voltage of 20 V for 2, 18, 24, and 48 h at room temperature. It was found that the longer the anodization time, the greater the number of pores formed on the CpTi G4 surface as revealed using the FE-SEM method, and the greater the surface roughness determined in profilometric tests. As the anodizing time increases, the amount of the drug in the form of gentamicin sulfate incorporated into the resulting pores decreases. The most favorable drug release kinetics profile determined via UV-VIS absorption spectroscopy was found for the CpTi G4 anodized for 2 h.
ISSN:2079-4983
2079-4983
DOI:10.3390/jfb15070180