One Century of Study: What We Learned about Paracoccidioides and How This Pathogen Contributed to Advances in Antifungal Therapy

Paracoccidioidomycosis (PCM) is a notable fungal infection restricted to Latin America. Since the first description of the disease by Lutz up to the present day, Brazilian researchers have contributed to the understanding of the life cycle of this pathogen and provided the possibility of new targets...

Full description

Saved in:
Bibliographic Details
Published in:Journal of fungi (Basel) 2021-02, Vol.7 (2), p.106
Main Authors: Seki Kioshima, Erika, de Souza Bonfim de Mendonça, Patrícia, de Melo Teixeira, Marcus, Grenier Capoci, Isis Regina, Amaral, André, Vilugron Rodrigues-Vendramini, Franciele Abigail, Lauton Simões, Bruna, Rodrigues Abadio, Ana Karina, Fernandes Matos, Larissa, Soares Felipe, Maria Sueli
Format: Article
Language:English
Subjects:
antifungal
Antifungal activity
Antigens
Biotechnology
Cloning
Developmental stages
Fungal infections
Fungi
Gene expression
Genomes
genomic
Genomics
Glycoproteins
Life cycles
new species discovery
new targets
Paracoccidioides
Pathogens
Pharmacodynamics
Phylogenetics
Proteins
Review
Serology
South American blastomycosis
Structure-function relationships
Thioredoxin
Toxicity
Virulence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Paracoccidioidomycosis (PCM) is a notable fungal infection restricted to Latin America. Since the first description of the disease by Lutz up to the present day, Brazilian researchers have contributed to the understanding of the life cycle of this pathogen and provided the possibility of new targets for antifungal therapy based on the structural and functional genomics of . In this context, approaches have selected molecules that act on specific targets, such as the thioredoxin system, with promising antifungal activity against . Some of these are already in advanced development stages. In addition, the application of nanostructured systems has addressed issues related to the high toxicity of conventional PCM therapy. Thus, the contribution of molecular biology and biotechnology to the advances achieved is unquestionable. However, it is still necessary to transcend the boundaries of synthetic chemistry, pharmaco-technics, and pharmacodynamics, aiming to turn promising molecules into newly available drugs for the treatment of fungal diseases.
ISSN:2309-608X
2309-608X
DOI:10.3390/jof7020106