Serum sRAGE, sRANKL and osteoprotegerin in subgroups of rheumatoid arthritis patients: biomarkers associated with iron and disease status

Soluble receptors are important for the balance between ligands and their membrane receptors. Changes in the expression of soluble receptors are associated with human diseases. The aim of this study was to determine the serum levels of sRAGE, sRANKL and OPG in subgroups of rheumatoid arthritis (RA)...

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Bibliographic Details
Published in:Biotechnology, biotechnological equipment biotechnological equipment, 2023-09, Vol.37 (1)
Main Authors: Delcheva, Ginka, Stefanova, Katya, Stankova, Teodora
Format: Article
Language:English
Subjects:
Advanced glycosylation end products
Antibodies
Arthritis
Autoimmune diseases
Biomarkers
Cell surface receptors
Disease
Ferritin
Immune status
inflammation
Iron
iron metabolism
Osteoprotegerin
Receptors
Rheumatoid arthritis
Serum levels
sRAGE
sRANKL
Subgroups
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Summary:Soluble receptors are important for the balance between ligands and their membrane receptors. Changes in the expression of soluble receptors are associated with human diseases. The aim of this study was to determine the serum levels of sRAGE, sRANKL and OPG in subgroups of rheumatoid arthritis (RA) patients according to the level of CRP and to assess the relationship of these parameters with markers of iron and disease status. The study involved 114 RA patients. The levels of sRAGE, sRANKL and OPG were higher in the subgroup with increased CRP level compared to the subgroup with normal CRP. sRAGE showed a significant positive correlation with sTfR (r = 0.435, p 
ISSN:1310-2818
1314-3530
DOI:10.1080/13102818.2023.2256428