Airway inflammation phenotype prediction in asthma patients using lung sound analysis with fractional exhaled nitric oxide

• Published in: Allergology international 2017-10, Vol.66 (4), p.581-585
• Main Authors: Shimoda, Terufumi, Obase, Yasushi, Nagasaka, Yukio, Nakano, Hiroshi, Kishikawa, Reiko, Iwanaga, Tomoaki
• Format: Article
• Language: English
• Subjects: Adult; Airway inflammation; Asthma - diagnosis; Asthma - metabolism; Asthma - physiopathology; Biomarkers; Bronchial asthma; Comorbidity; Exhalation; Exhaled nitric oxide; Female; Humans; Lung sound analysis; Male; Middle Aged; Nitric Oxide - metabolism; Phenotype; Prognosis; Respiratory Function Tests; Respiratory Sounds; Sputum
• ISSN: 1323-8930; 1440-1592
• DOI: 10.1016/j.alit.2017.02.016

We previously reported the results of lung sound analysis in patients with bronchial asthma and demonstrated that the exhalation-to-inhalation sound pressure ratio in the low frequency range between 100 and 200 Hz (E/I LF) was correlated with the presence of airway inflammation and airway obstruction. We classified asthma patients by airway inflammation phenotype using the induced sputum eosinophil and neutrophil ratio and determined whether this phenotype could be predicted using E/I LF and fractional exhaled nitric oxide values. Steroid-naive bronchial asthma patients were classified into four phenotypes, including “Low inflammation” (35 patients), “Eosinophilic type” (58 patients), “Neutrophilic type” (15 patients), and “Mixed type” (15 patients) based on the results of induced sputum examinations. The E/I LF data and FeNO levels were then evaluated for the four phenotype groups; the prediction powers of these two indices were then analyzed for each phenotype. The median E/I LF value was highest in the “Mixed type” and lowest in the “Low inflammation” group. FeNO differentiated between the “Low inflammation” and “Eosinophilic type” groups, “Low inflammation” and “Neutrophilic type” groups, and “Neutrophilic type” and “Mixed type” (p