Loss of Ambulation Due to Calcific Myonecrosis: A Rare but Reversible Complication of Wilson's Disease

We report two cases of established Wilson's disease (WD) presenting with calcific myonecrosis of the pelvic girdle in association with pelvic fractures. Despite initial improvement with chelation, subacute worsening of ambulation in both led to a consideration of neurologic deterioration on che...

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Bibliographic Details
Published in:Annals of the Indian Academy of Neurology 2024-11, Vol.27 (6), p.724-726
Main Authors: Vaingankar, Abhishek, Garg, Divyani, Agarwal, Ayush, Radhakrishnan, Divya M, Pandit, Awadh Kishor, Tripathi, Madhavi, Srivastava, Achal K
Format: Article
Language:English
Subjects:
Bones
Calcification (ectopic)
Care and treatment
Case studies
Chelation
Complications and side effects
copper
Fracture
Fractures
Muscles
Myonecrosis
Necrosis
osseomuscular
Pelvis
Wilson's disease
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Summary:We report two cases of established Wilson's disease (WD) presenting with calcific myonecrosis of the pelvic girdle in association with pelvic fractures. Despite initial improvement with chelation, subacute worsening of ambulation in both led to a consideration of neurologic deterioration on chelation therapy. However, evaluation revealed calcific myonecrosis of the hip joint and adjacent muscles as the cause. Both patients improved with intensive rehabilitation. A review of literature indicates that although osseomuscular complications are reported in WD, calcific myonecrosis is a hitherto unknown entity which, if recognized early, may be reversed, preventing disability and unnecessary change in chelation regimens.
ISSN:0972-2327
1998-3549
DOI:10.4103/aian.aian_419_24