Disease progression in Parkinson‘s disease patients with subjective cognitive complaint

Objective Little is known about the disease progression of Parkinson's disease patients with subjective cognitive complaint (PD‐SCC). This longitudinal cohort study aims to compare the progression of clinical features and quality of life (QoL) in PD patients with normal cognition (NC), SCC, and...

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Published in:Annals of clinical and translational neurology 2021-10, Vol.8 (10), p.2096-2104
Main Authors: Han, Lin‐Lin, Wang, Lan, Xu, Zhi‐Heng, Liang, Xiao‐Niu, Zhang, Meng‐Wei, Fan, Yun, Sun, Yi‐Min, Liu, Feng‐Tao, Yu, Wen‐Bo, Tang, Yi‐Lin
Format: Article
Language:English
Subjects:
Alzheimer's disease
Cognition & reasoning
Cognitive ability
Dementia
Education
Longitudinal studies
Neuropsychology
Parkinson's disease
Patients
Questionnaires
Task forces
Variance analysis
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Summary:Objective Little is known about the disease progression of Parkinson's disease patients with subjective cognitive complaint (PD‐SCC). This longitudinal cohort study aims to compare the progression of clinical features and quality of life (QoL) in PD patients with normal cognition (NC), SCC, and mild cognitive impairment (MCI). Methods A total of 383 PD patients were enrolled, including 189 PD‐NC patients, 59 PD‐SCC patients, and 135 PD‐MCI patients, with 1–7 years of follow‐up. Linear mixed models were applied to evaluate longitudinal changes in motor symptoms, nonmotor features (cognitive impairment, depression, and excessive daytime sleepiness), and QoL in PD. Results At baseline, PD‐SCC patients had lower Beck Depression Inventory (BDI) scores and Parkinson's Disease Questionnaire‐39 (PDQ‐39) scores than PD‐NC patients (all p 
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.51461