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Disease progression in Parkinson‘s disease patients with subjective cognitive complaint
Objective Little is known about the disease progression of Parkinson's disease patients with subjective cognitive complaint (PD‐SCC). This longitudinal cohort study aims to compare the progression of clinical features and quality of life (QoL) in PD patients with normal cognition (NC), SCC, and...
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| Published in: | Annals of clinical and translational neurology 2021-10, Vol.8 (10), p.2096-2104 |
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| Main Authors: | , , , , , , , , , |
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| container_end_page | 2104 |
| container_issue | 10 |
| container_start_page | 2096 |
| container_title | Annals of clinical and translational neurology |
| container_volume | 8 |
| creator | Han, Lin‐Lin Wang, Lan Xu, Zhi‐Heng Liang, Xiao‐Niu Zhang, Meng‐Wei Fan, Yun Sun, Yi‐Min Liu, Feng‐Tao Yu, Wen‐Bo Tang, Yi‐Lin |
| description | Objective
Little is known about the disease progression of Parkinson's disease patients with subjective cognitive complaint (PD‐SCC). This longitudinal cohort study aims to compare the progression of clinical features and quality of life (QoL) in PD patients with normal cognition (NC), SCC, and mild cognitive impairment (MCI).
Methods
A total of 383 PD patients were enrolled, including 189 PD‐NC patients, 59 PD‐SCC patients, and 135 PD‐MCI patients, with 1–7 years of follow‐up. Linear mixed models were applied to evaluate longitudinal changes in motor symptoms, nonmotor features (cognitive impairment, depression, and excessive daytime sleepiness), and QoL in PD.
Results
At baseline, PD‐SCC patients had lower Beck Depression Inventory (BDI) scores and Parkinson's Disease Questionnaire‐39 (PDQ‐39) scores than PD‐NC patients (all p |
| doi_str_mv | 10.1002/acn3.51461 |
| format | article |
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Little is known about the disease progression of Parkinson's disease patients with subjective cognitive complaint (PD‐SCC). This longitudinal cohort study aims to compare the progression of clinical features and quality of life (QoL) in PD patients with normal cognition (NC), SCC, and mild cognitive impairment (MCI).
Methods
A total of 383 PD patients were enrolled, including 189 PD‐NC patients, 59 PD‐SCC patients, and 135 PD‐MCI patients, with 1–7 years of follow‐up. Linear mixed models were applied to evaluate longitudinal changes in motor symptoms, nonmotor features (cognitive impairment, depression, and excessive daytime sleepiness), and QoL in PD.
Results
At baseline, PD‐SCC patients had lower Beck Depression Inventory (BDI) scores and Parkinson's Disease Questionnaire‐39 (PDQ‐39) scores than PD‐NC patients (all p < 0.05). Longitudinal analyses revealed that the PD‐SCC group exhibited faster progression in terms of BDI scores (p = 0.042) and PDQ‐39 scores (p = 0.035) than the PD‐NC group. The PD‐MCI group exhibited faster progression rates in the Epworth Sleepiness Scale scores (p = 0.001) and PDQ‐39 scores (p = 0.005) than the PD‐NC group. In addition, the PD‐SCC group exhibited a greater reduction in attention (Trail Making Test Part A, p = 0.047) and executive function (Stroop Color‐Word Test, p = 0.037) than the PD‐NC group.
Interpretation
PD‐SCC patients exhibited faster deterioration of depression and QoL than PD‐NC patients, and SCC may be an indicator of initial attention and executive function decline in PD. Our findings provided a more accurate prognosis in PD‐SCC patients.</description><identifier>ISSN: 2328-9503</identifier><identifier>EISSN: 2328-9503</identifier><identifier>DOI: 10.1002/acn3.51461</identifier><identifier>PMID: 34595848</identifier><language>eng</language><publisher>Bognor Regis: John Wiley & Sons, Inc</publisher><subject>Alzheimer's disease ; Cognition & reasoning ; Cognitive ability ; Dementia ; Education ; Longitudinal studies ; Neuropsychology ; Parkinson's disease ; Patients ; Questionnaires ; Task forces ; Variance analysis</subject><ispartof>Annals of clinical and translational neurology, 2021-10, Vol.8 (10), p.2096-2104</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC on behalf of American Neurological Association</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3731-c12a21b0567893da082609ffd03c2fa1ce1d53dc253bed72f31f433f4c9e3e9a3</citedby><cites>FETCH-LOGICAL-c3731-c12a21b0567893da082609ffd03c2fa1ce1d53dc253bed72f31f433f4c9e3e9a3</cites><orcidid>0000-0003-2819-6554 ; 0000-0001-7688-1631</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2583552453/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2583552453?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,11541,25731,27901,27902,36989,44566,46027,46451,53766,53768,74869</link.rule.ids></links><search><creatorcontrib>Han, Lin‐Lin</creatorcontrib><creatorcontrib>Wang, Lan</creatorcontrib><creatorcontrib>Xu, Zhi‐Heng</creatorcontrib><creatorcontrib>Liang, Xiao‐Niu</creatorcontrib><creatorcontrib>Zhang, Meng‐Wei</creatorcontrib><creatorcontrib>Fan, Yun</creatorcontrib><creatorcontrib>Sun, Yi‐Min</creatorcontrib><creatorcontrib>Liu, Feng‐Tao</creatorcontrib><creatorcontrib>Yu, Wen‐Bo</creatorcontrib><creatorcontrib>Tang, Yi‐Lin</creatorcontrib><title>Disease progression in Parkinson‘s disease patients with subjective cognitive complaint</title><title>Annals of clinical and translational neurology</title><description>Objective
Little is known about the disease progression of Parkinson's disease patients with subjective cognitive complaint (PD‐SCC). This longitudinal cohort study aims to compare the progression of clinical features and quality of life (QoL) in PD patients with normal cognition (NC), SCC, and mild cognitive impairment (MCI).
Methods
A total of 383 PD patients were enrolled, including 189 PD‐NC patients, 59 PD‐SCC patients, and 135 PD‐MCI patients, with 1–7 years of follow‐up. Linear mixed models were applied to evaluate longitudinal changes in motor symptoms, nonmotor features (cognitive impairment, depression, and excessive daytime sleepiness), and QoL in PD.
Results
At baseline, PD‐SCC patients had lower Beck Depression Inventory (BDI) scores and Parkinson's Disease Questionnaire‐39 (PDQ‐39) scores than PD‐NC patients (all p < 0.05). Longitudinal analyses revealed that the PD‐SCC group exhibited faster progression in terms of BDI scores (p = 0.042) and PDQ‐39 scores (p = 0.035) than the PD‐NC group. The PD‐MCI group exhibited faster progression rates in the Epworth Sleepiness Scale scores (p = 0.001) and PDQ‐39 scores (p = 0.005) than the PD‐NC group. In addition, the PD‐SCC group exhibited a greater reduction in attention (Trail Making Test Part A, p = 0.047) and executive function (Stroop Color‐Word Test, p = 0.037) than the PD‐NC group.
Interpretation
PD‐SCC patients exhibited faster deterioration of depression and QoL than PD‐NC patients, and SCC may be an indicator of initial attention and executive function decline in PD. Our findings provided a more accurate prognosis in PD‐SCC patients.</description><subject>Alzheimer's disease</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Dementia</subject><subject>Education</subject><subject>Longitudinal studies</subject><subject>Neuropsychology</subject><subject>Parkinson's disease</subject><subject>Patients</subject><subject>Questionnaires</subject><subject>Task forces</subject><subject>Variance analysis</subject><issn>2328-9503</issn><issn>2328-9503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kb9OHDEQh60oESCg4QlWoot0xPasd71NJHSBgIRCiqRIZc36z-Fjz77YeyA6HiPPx5PEsJcoNKk88nzz2aMfIUeMnjBK-QfUAU4Eqxv2huxx4HLWCQpv_6l3yWHOS0opY1xAy3fILtSiE7KWe-THJ58tZlutU1wkm7OPofKh-orp1occw9Pjr1yZPxCO3oYxV_d-vKnypl9aPfo7W-m4CH5brdYD-jAekHcOh2wPt-c--X5-9m1-Mbu6_nw5P72aaWiBzTTjyFlPRdPKDgxSyRvaOWcoaO6QacuMAKPL13trWu6AuRrA1bqzYDuEfXI5eU3EpVonv8L0oCJ69XIR00JhGr0erGp7oNTxMtg1NW16tBQptj1DKVlruuL6OLnWm35ljS67JhxeSV93gr9Ri3inpOCyFrIIjreCFH9ubB7VMm5SKPsrXtpC8FpAod5PlE4x52Td3xcYVc-pqudU1UuqBWYTfO8H-_AfUp3Ov8A08xvGZqTA</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Han, Lin‐Lin</creator><creator>Wang, Lan</creator><creator>Xu, Zhi‐Heng</creator><creator>Liang, Xiao‐Niu</creator><creator>Zhang, Meng‐Wei</creator><creator>Fan, Yun</creator><creator>Sun, Yi‐Min</creator><creator>Liu, Feng‐Tao</creator><creator>Yu, Wen‐Bo</creator><creator>Tang, Yi‐Lin</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><general>Wiley</general><scope>24P</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2819-6554</orcidid><orcidid>https://orcid.org/0000-0001-7688-1631</orcidid></search><sort><creationdate>202110</creationdate><title>Disease progression in Parkinson‘s disease patients with subjective cognitive complaint</title><author>Han, Lin‐Lin ; Wang, Lan ; Xu, Zhi‐Heng ; Liang, Xiao‐Niu ; Zhang, Meng‐Wei ; Fan, Yun ; Sun, Yi‐Min ; Liu, Feng‐Tao ; Yu, Wen‐Bo ; Tang, Yi‐Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3731-c12a21b0567893da082609ffd03c2fa1ce1d53dc253bed72f31f433f4c9e3e9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alzheimer's disease</topic><topic>Cognition & reasoning</topic><topic>Cognitive ability</topic><topic>Dementia</topic><topic>Education</topic><topic>Longitudinal studies</topic><topic>Neuropsychology</topic><topic>Parkinson's disease</topic><topic>Patients</topic><topic>Questionnaires</topic><topic>Task forces</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Lin‐Lin</creatorcontrib><creatorcontrib>Wang, Lan</creatorcontrib><creatorcontrib>Xu, Zhi‐Heng</creatorcontrib><creatorcontrib>Liang, Xiao‐Niu</creatorcontrib><creatorcontrib>Zhang, Meng‐Wei</creatorcontrib><creatorcontrib>Fan, Yun</creatorcontrib><creatorcontrib>Sun, Yi‐Min</creatorcontrib><creatorcontrib>Liu, Feng‐Tao</creatorcontrib><creatorcontrib>Yu, Wen‐Bo</creatorcontrib><creatorcontrib>Tang, Yi‐Lin</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Annals of clinical and translational neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Lin‐Lin</au><au>Wang, Lan</au><au>Xu, Zhi‐Heng</au><au>Liang, Xiao‐Niu</au><au>Zhang, Meng‐Wei</au><au>Fan, Yun</au><au>Sun, Yi‐Min</au><au>Liu, Feng‐Tao</au><au>Yu, Wen‐Bo</au><au>Tang, Yi‐Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disease progression in Parkinson‘s disease patients with subjective cognitive complaint</atitle><jtitle>Annals of clinical and translational neurology</jtitle><date>2021-10</date><risdate>2021</risdate><volume>8</volume><issue>10</issue><spage>2096</spage><epage>2104</epage><pages>2096-2104</pages><issn>2328-9503</issn><eissn>2328-9503</eissn><abstract>Objective
Little is known about the disease progression of Parkinson's disease patients with subjective cognitive complaint (PD‐SCC). This longitudinal cohort study aims to compare the progression of clinical features and quality of life (QoL) in PD patients with normal cognition (NC), SCC, and mild cognitive impairment (MCI).
Methods
A total of 383 PD patients were enrolled, including 189 PD‐NC patients, 59 PD‐SCC patients, and 135 PD‐MCI patients, with 1–7 years of follow‐up. Linear mixed models were applied to evaluate longitudinal changes in motor symptoms, nonmotor features (cognitive impairment, depression, and excessive daytime sleepiness), and QoL in PD.
Results
At baseline, PD‐SCC patients had lower Beck Depression Inventory (BDI) scores and Parkinson's Disease Questionnaire‐39 (PDQ‐39) scores than PD‐NC patients (all p < 0.05). Longitudinal analyses revealed that the PD‐SCC group exhibited faster progression in terms of BDI scores (p = 0.042) and PDQ‐39 scores (p = 0.035) than the PD‐NC group. The PD‐MCI group exhibited faster progression rates in the Epworth Sleepiness Scale scores (p = 0.001) and PDQ‐39 scores (p = 0.005) than the PD‐NC group. In addition, the PD‐SCC group exhibited a greater reduction in attention (Trail Making Test Part A, p = 0.047) and executive function (Stroop Color‐Word Test, p = 0.037) than the PD‐NC group.
Interpretation
PD‐SCC patients exhibited faster deterioration of depression and QoL than PD‐NC patients, and SCC may be an indicator of initial attention and executive function decline in PD. Our findings provided a more accurate prognosis in PD‐SCC patients.</abstract><cop>Bognor Regis</cop><pub>John Wiley & Sons, Inc</pub><pmid>34595848</pmid><doi>10.1002/acn3.51461</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2819-6554</orcidid><orcidid>https://orcid.org/0000-0001-7688-1631</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of clinical and translational neurology, 2021-10, Vol.8 (10), p.2096-2104 |
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| language | eng |
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| source | PubMed (Medline); Wiley Online Library Open Access; Publicly Available Content Database |
| subjects | Alzheimer's disease Cognition & reasoning Cognitive ability Dementia Education Longitudinal studies Neuropsychology Parkinson's disease Patients Questionnaires Task forces Variance analysis |
| title | Disease progression in Parkinson‘s disease patients with subjective cognitive complaint |
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