Palonosetron: A novel approach to control postoperative nausea and vomiting in day care surgery

• Published in: Saudi journal of anaesthesia 2011-01, Vol.5 (1), p.19-24
• Main Authors: Bajwa, Sukhminderjit Singh, Bajwa, Sukhwinder Kaur, Kaur, Jasbir, Sharma, Veenita, Singh, Amarjit, Singh, Anita, Goraya, Sps, Parmar, Ss, Singh, Kamaljit
• Format: Article
• Language: English
• Subjects: Anesthesia; Complications and side effects; Day care surgery; Gastrointestinal agents; Medical research; Medicine, Experimental; Narcotics; Nausea; ondansetron; Original; palonosetron; ponv0; Prevention; Surgery
• ISSN: 1658-354X; 0975-3125
• DOI: 10.4103/1658-354X.76484

Postoperative nausea and vomiting (PONV) is one of the complications which hamper the successful implementation of day care surgical procedure in spite of the availability of so many antiemetic drugs and regimens for its prevention. The aim was to compare the prophylactic effects of intravenously (IV) administered ondansetron and palonosetron on PONV prevention in patients undergoing laparoscopic gynecological surgery under general anesthesia. A prospective double-blind study comprised of 60 ASAI/II female patients between the age group of 25 and 40 years was carried out in the Departments of Anesthesiology and Obstetrics and Gynecology of our institute. Patients were randomly divided into two groups of 30 patients each in a double-blind manner. Group I received 8 mg of inj. ondansetron IV while group II received inj. palonosetron 0.075 mg IV 5 minutes before the induction of anesthesia. The need for rescue antiemetics, episodes of PONV and other side effects were observed for 6 hours in the postanesthesia care unit and thereafter complaints were received on phone after the discharge. At the end of study, results were compiled and statistical data was subjected to statistical analysis using Student two-tailed 't' and χ(2) test and value of P