Population-wide active case finding and prevention for tuberculosis and leprosy elimination in Kiribati: the PEARL study protocol

IntroductionPopulation-wide interventions offer a pathway to tuberculosis (TB) and leprosy elimination, but ‘real-world’ implementation in a high-burden setting using a combined approach has not been demonstrated. This implementation study aims to demonstrate the feasibility and evaluate the effect...

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Bibliographic Details
Published in:BMJ open 2022-04, Vol.12 (4), p.e055295-e055295
Main Authors: Coleman, Mikaela, Hill, Jeremy, Timeon, Eretii, Tonganibeia, Alfred, Eromanga, Baraniko, Islam, Tauhid, Trauer, James M, Chambers, Stephen T, Christensen, Amanda, Fox, Greg J, Marks, Guy B, Britton, Warwick J, Marais, Ben J
Format: Article
Language:English
Subjects:
Adults
Child
COVID-19 vaccines
Disease prevention
Disease transmission
Drug resistance
Epidemiology
HIV
Households
Human immunodeficiency virus
Humans
Immunization
Infection control
Infections
Intervention
Leprosy
Leprosy - diagnosis
Leprosy - epidemiology
Leprosy - prevention & control
Micronesia - epidemiology
Microscopy
Mycobacterium tuberculosis
Population
PREVENTIVE MEDICINE
Public health
Tuberculosis
Tuberculosis - epidemiology
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Summary:IntroductionPopulation-wide interventions offer a pathway to tuberculosis (TB) and leprosy elimination, but ‘real-world’ implementation in a high-burden setting using a combined approach has not been demonstrated. This implementation study aims to demonstrate the feasibility and evaluate the effect of population-wide screening, treatment and prevention on TB and leprosy incidence rates, as well as TB transmission.Methods and analysisA non-randomised ‘screen-and-treat’ intervention conducted in the Pacific atoll of South Tarawa, Kiribati. Households are enumerated and all residents ≥3 years, as well as children
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2021-055295