Perception of a conserved family of plant signalling peptides by the receptor kinase HSL3

Plant genomes encode hundreds of secreted peptides; however, relatively few have been characterised. We report here an uncharacterised, stress-induced family of plant signalling peptides, which we call CTNIPs. Based on the role of the common co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINAS...

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Published in:eLife 2022-05, Vol.11
Main Authors: Rhodes, Jack, Roman, Andra-Octavia, Bjornson, Marta, Brandt, Benjamin, Derbyshire, Paul, Wyler, Michele, Schmid, Marc W, Menke, Frank L H, Santiago, Julia, Zipfel, Cyril
Format: Article
Language:English
Subjects:
Amino acids
Angiosperms
Coevolution
evolution
Experiments
Genomes
immunity
Kinases
Ligands
peptide hormones
Peptides
phytocytokine
Plant Biology
Proteins
Proteomics
receptor kinase
Short Report
signalling
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Summary:Plant genomes encode hundreds of secreted peptides; however, relatively few have been characterised. We report here an uncharacterised, stress-induced family of plant signalling peptides, which we call CTNIPs. Based on the role of the common co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) in CTNIP-induced responses, we identified in the orphan receptor kinase HAESA-LIKE 3 (HSL3) as the CTNIP receptor via a proteomics approach. CTNIP-binding, ligand-triggered complex formation with BAK1, and induced downstream responses all involve HSL3. Notably, the HSL3-CTNIP signalling module is evolutionarily conserved amongst most extant angiosperms. The identification of this novel signalling module will further shed light on the diverse functions played by plant signalling peptides and will provide insights into receptor-ligand co-evolution.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.74687