Plasmodium vivax Biology: Insights Provided by Genomics, Transcriptomics and Proteomics

During the last decade, the vast omics field has revolutionized biological research, especially the genomics, transcriptomics and proteomics branches, as technological tools become available to the field researcher and allow difficult question-driven studies to be addressed. Parasitology has greatly...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2018-02, Vol.8, p.34-34
Main Authors: Bourgard, Catarina, Albrecht, Letusa, Kayano, Ana C A V, Sunnerhagen, Per, Costa, Fabio T M
Format: Article
Language:English
Subjects:
Evolution, Molecular
Gene Expression Profiling - methods
Gene Expression Regulation
genome
Genome, Protozoan
Genomics
Host-Parasite Interactions
Humans
malaria
Malaria, Vivax - parasitology
Malaria, Vivax - prevention & control
Metabolome
Metabolomics - methods
Microbiology
Microbiology in the Medical Area
Mikrobiologi
Mikrobiologi inom det medicinska området
Plasmodium vivax
Plasmodium vivax - physiology
proteome
Proteomics
transcriptome
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Summary:During the last decade, the vast omics field has revolutionized biological research, especially the genomics, transcriptomics and proteomics branches, as technological tools become available to the field researcher and allow difficult question-driven studies to be addressed. Parasitology has greatly benefited from next generation sequencing (NGS) projects, which have resulted in a broadened comprehension of basic parasite molecular biology, ecology and epidemiology. Malariology is one example where application of this technology has greatly contributed to a better understanding of spp. biology and host-parasite interactions. Among the several parasite species that cause human malaria, the neglected presents great research challenges, as culturing is not yet feasible and functional assays are heavily limited. Therefore, there are gaps in our biology knowledge that affect decisions for control policies aiming to eradicate vivax malaria in the near future. In this review, we provide a snapshot of key discoveries already achieved in sequencing projects, focusing on developments, hurdles, and limitations currently faced by the research community, as well as perspectives on future vivax malaria research.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2018.00034