A novel variant of genotype 7b hepatitis C virus emphasizing viral hepatitis elimination challenges for sub-Saharan Africa

Sub-Saharan Africa has approximately 10.15 million people viraemic with chronic hepatitis C virus infection, extensive genotype and sub-genotype diversity is present, in addition to novel hepatitis C genotypes. Many of the unusual genotypes have extensive baseline resistance associated substitutions...

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Bibliographic Details
Published in:The Pan African medical journal 2020-07, Vol.36 (232), p.232
Main Authors: Sonderup, Mark Wayne, Smuts, Heidi, Spearman, Catherine Wendy
Format: Article
Language:English
Subjects:
Africa South of the Sahara
Aged
Antiviral Agents - administration & dosage
Case Report
Drug Resistance, Viral
elimination programmes
Female
Genotype
genotype diversity
Hepacivirus - genetics
hepatitis c
Hepatitis C, Chronic - diagnosis
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - virology
Humans
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Summary:Sub-Saharan Africa has approximately 10.15 million people viraemic with chronic hepatitis C virus infection, extensive genotype and sub-genotype diversity is present, in addition to novel hepatitis C genotypes. Many of the unusual genotypes have extensive baseline resistance associated substitutions with direct acting antiviral therapy treatment outcome data, limited. We report a patient found to have a novel genotype 7b variant with extensive baseline resistance associated substitutions. There is a clear need for a better understanding of the virological characteristics of hepatitis C populations in sub-Saharan Africa to guide best optimal treatment decisions in national hepatitis C elimination programmes.
ISSN:1937-8688
1937-8688
DOI:10.11604/pamj.2020.36.232.24726