Metachronous Liver Metastasis from Alpha-Fetoprotein-Producing Gastric Cancer Successfully Treated with Capecitabine/Oxaliplatin Combination Chemotherapy

A consensus regarding the treatment of recurrent alpha-fetoprotein-producing gastric carcinoma due to its rarity is lacking. We herein describe a case of such a carcinoma that was associated with metachronous liver metastasis. A 73-year-old man was referred for the surgical treatment of a type 2 gas...

Full description

Saved in:
Bibliographic Details
Published in:Case reports in surgery 2022-08, Vol.2022, p.1-9
Main Authors: Furukawa, Soichi, Kobayashi, Takashi, Shiono, Saori, Nishinakagawa, Shuta
Format: Article
Language:English
Subjects:
Adenocarcinoma
Antigens
Blood tests
Cancer
Cancer therapies
Care and treatment
Case Report
Case reports
Chemotherapy
Drug therapy, Combination
Epidermal growth factor
Gastrectomy
Gastric cancer
Gastrointestinal surgery
Glycoproteins
Growth factors
Hepatectomy
Liver
Liver cancer
Lymph nodes
Lymphatic system
Magnetic resonance imaging
Medical prognosis
Metastases
Metastasis
Oxaliplatin
Stomach cancer
Tomography
Tumors
α-Fetoprotein
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c412t-34ed1e7d1f306d17ad1ce7ad565fddacab93480e0c7a276e4e434d38cfce1e763
container_end_page 9
container_issue
container_start_page 1
container_title Case reports in surgery
container_volume 2022
creator Furukawa, Soichi
Kobayashi, Takashi
Shiono, Saori
Nishinakagawa, Shuta
description A consensus regarding the treatment of recurrent alpha-fetoprotein-producing gastric carcinoma due to its rarity is lacking. We herein describe a case of such a carcinoma that was associated with metachronous liver metastasis. A 73-year-old man was referred for the surgical treatment of a type 2 gastric tumor that extended from the greater curvature of the gastric corpus to the pylorus. As no remote metastases were detected, the patient underwent open total gastrectomy with lymphadenectomy and Roux-en-Y reconstruction. Histopathological examination revealed regional lymph node metastasis and the invasion of the muscularis propria by a moderately differentiated adenocarcinoma. Immunostaining of the primary tumor was positive for alpha-fetoprotein and negative for human epidermal growth factor receptor 2. Serum alpha-fetoprotein levels decreased to within normal limits after eight courses of S-1 monotherapy; however, levels started to increase, and a hypovascular nodule in segment 5/6 of the liver was detected 3.5 years later. Serum alpha-fetoprotein levels returned to the normal range, and the tumor was undetectable after four courses of capecitabine and oxaliplatin therapy. No recurrence was detected at 1.5-year follow-up. This case demonstrates that combined capecitabine and oxaliplatin therapy can successfully treat metachronous liver metastasis from alpha-fetoprotein-producing gastric carcinoma.
doi_str_mv 10.1155/2022/2700394
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_7b68a483978244dabcd03dd741480e6b</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A821430807</galeid><doaj_id>oai_doaj_org_article_7b68a483978244dabcd03dd741480e6b</doaj_id><sourcerecordid>A821430807</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-34ed1e7d1f306d17ad1ce7ad565fddacab93480e0c7a276e4e434d38cfce1e763</originalsourceid><addsrcrecordid>eNp9kt9q2zAUxs3YWEvXuz2AYZebG_2zZd8MQmi7QkYH666FLB3HCrbkSXK7PMredkoTOgJjkpAOn77zk4ROlr3H6ArjslwQRMiCcIRow15l5wQ1qKga3Lx-iRE6yy5D2KLUKkRwWb_NzmiFSlyV-Dz7_RWiVL131s0hX5tH8PleCmmYkHfejflymHpZ3EB0k3cRjC2-eadnZewmv01Ob1S-klal1O-zUhBCNw_DLn_wICPo_MnEPhkmUCbK1lhY3P-Sg5kGGY3NV25MWgpdinsYXezBy2n3LnvTySHA5XG9yH7cXD-svhTr-9u71XJdKIZJLCgDjYFr3FFUacylxgrSXFZlp7VUsm0oqxEgxSXhFTBglGlaq05ByqvoRXZ34Gont2LyZpR-J5w04llwfiOkj0YNIHhb1ZLVtOE1YUzLVmlEteYM70-o2sT6fGBNczuCVmCjl8MJ9HTHml5s3KNoGOEU8QT4cAR493OGEMXWzd6m94v0y03ZlJzgv66NTLcytnMJpkYTlFjWBDOK6mfW1T9cqWsYjXIWOpP0k4RPhwTlXQgeupeLYyT25Sb25SaO5ZbsHw_23lgtn8z_3X8AWKfV1Q</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2709595721</pqid></control><display><type>article</type><title>Metachronous Liver Metastasis from Alpha-Fetoprotein-Producing Gastric Cancer Successfully Treated with Capecitabine/Oxaliplatin Combination Chemotherapy</title><source>PubMed (Medline)</source><source>Wiley Online Library Open Access</source><source>Publicly Available Content (ProQuest)</source><creator>Furukawa, Soichi ; Kobayashi, Takashi ; Shiono, Saori ; Nishinakagawa, Shuta</creator><contributor>Mantas, Dimitrios ; Dimitrios Mantas</contributor><creatorcontrib>Furukawa, Soichi ; Kobayashi, Takashi ; Shiono, Saori ; Nishinakagawa, Shuta ; Mantas, Dimitrios ; Dimitrios Mantas</creatorcontrib><description>A consensus regarding the treatment of recurrent alpha-fetoprotein-producing gastric carcinoma due to its rarity is lacking. We herein describe a case of such a carcinoma that was associated with metachronous liver metastasis. A 73-year-old man was referred for the surgical treatment of a type 2 gastric tumor that extended from the greater curvature of the gastric corpus to the pylorus. As no remote metastases were detected, the patient underwent open total gastrectomy with lymphadenectomy and Roux-en-Y reconstruction. Histopathological examination revealed regional lymph node metastasis and the invasion of the muscularis propria by a moderately differentiated adenocarcinoma. Immunostaining of the primary tumor was positive for alpha-fetoprotein and negative for human epidermal growth factor receptor 2. Serum alpha-fetoprotein levels decreased to within normal limits after eight courses of S-1 monotherapy; however, levels started to increase, and a hypovascular nodule in segment 5/6 of the liver was detected 3.5 years later. Serum alpha-fetoprotein levels returned to the normal range, and the tumor was undetectable after four courses of capecitabine and oxaliplatin therapy. No recurrence was detected at 1.5-year follow-up. This case demonstrates that combined capecitabine and oxaliplatin therapy can successfully treat metachronous liver metastasis from alpha-fetoprotein-producing gastric carcinoma.</description><identifier>ISSN: 2090-6900</identifier><identifier>EISSN: 2090-6919</identifier><identifier>DOI: 10.1155/2022/2700394</identifier><identifier>PMID: 36051651</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Adenocarcinoma ; Antigens ; Blood tests ; Cancer ; Cancer therapies ; Care and treatment ; Case Report ; Case reports ; Chemotherapy ; Drug therapy, Combination ; Epidermal growth factor ; Gastrectomy ; Gastric cancer ; Gastrointestinal surgery ; Glycoproteins ; Growth factors ; Hepatectomy ; Liver ; Liver cancer ; Lymph nodes ; Lymphatic system ; Magnetic resonance imaging ; Medical prognosis ; Metastases ; Metastasis ; Oxaliplatin ; Stomach cancer ; Tomography ; Tumors ; α-Fetoprotein</subject><ispartof>Case reports in surgery, 2022-08, Vol.2022, p.1-9</ispartof><rights>Copyright © 2022 Soichi Furukawa et al.</rights><rights>COPYRIGHT 2022 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2022 Soichi Furukawa et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Soichi Furukawa et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c412t-34ed1e7d1f306d17ad1ce7ad565fddacab93480e0c7a276e4e434d38cfce1e763</cites><orcidid>0000-0002-3588-8885</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2709595721/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2709595721?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,44590,53791,53793,74998</link.rule.ids></links><search><contributor>Mantas, Dimitrios</contributor><contributor>Dimitrios Mantas</contributor><creatorcontrib>Furukawa, Soichi</creatorcontrib><creatorcontrib>Kobayashi, Takashi</creatorcontrib><creatorcontrib>Shiono, Saori</creatorcontrib><creatorcontrib>Nishinakagawa, Shuta</creatorcontrib><title>Metachronous Liver Metastasis from Alpha-Fetoprotein-Producing Gastric Cancer Successfully Treated with Capecitabine/Oxaliplatin Combination Chemotherapy</title><title>Case reports in surgery</title><description>A consensus regarding the treatment of recurrent alpha-fetoprotein-producing gastric carcinoma due to its rarity is lacking. We herein describe a case of such a carcinoma that was associated with metachronous liver metastasis. A 73-year-old man was referred for the surgical treatment of a type 2 gastric tumor that extended from the greater curvature of the gastric corpus to the pylorus. As no remote metastases were detected, the patient underwent open total gastrectomy with lymphadenectomy and Roux-en-Y reconstruction. Histopathological examination revealed regional lymph node metastasis and the invasion of the muscularis propria by a moderately differentiated adenocarcinoma. Immunostaining of the primary tumor was positive for alpha-fetoprotein and negative for human epidermal growth factor receptor 2. Serum alpha-fetoprotein levels decreased to within normal limits after eight courses of S-1 monotherapy; however, levels started to increase, and a hypovascular nodule in segment 5/6 of the liver was detected 3.5 years later. Serum alpha-fetoprotein levels returned to the normal range, and the tumor was undetectable after four courses of capecitabine and oxaliplatin therapy. No recurrence was detected at 1.5-year follow-up. This case demonstrates that combined capecitabine and oxaliplatin therapy can successfully treat metachronous liver metastasis from alpha-fetoprotein-producing gastric carcinoma.</description><subject>Adenocarcinoma</subject><subject>Antigens</subject><subject>Blood tests</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Chemotherapy</subject><subject>Drug therapy, Combination</subject><subject>Epidermal growth factor</subject><subject>Gastrectomy</subject><subject>Gastric cancer</subject><subject>Gastrointestinal surgery</subject><subject>Glycoproteins</subject><subject>Growth factors</subject><subject>Hepatectomy</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Magnetic resonance imaging</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Oxaliplatin</subject><subject>Stomach cancer</subject><subject>Tomography</subject><subject>Tumors</subject><subject>α-Fetoprotein</subject><issn>2090-6900</issn><issn>2090-6919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kt9q2zAUxs3YWEvXuz2AYZebG_2zZd8MQmi7QkYH666FLB3HCrbkSXK7PMredkoTOgJjkpAOn77zk4ROlr3H6ArjslwQRMiCcIRow15l5wQ1qKga3Lx-iRE6yy5D2KLUKkRwWb_NzmiFSlyV-Dz7_RWiVL131s0hX5tH8PleCmmYkHfejflymHpZ3EB0k3cRjC2-eadnZewmv01Ob1S-klal1O-zUhBCNw_DLn_wICPo_MnEPhkmUCbK1lhY3P-Sg5kGGY3NV25MWgpdinsYXezBy2n3LnvTySHA5XG9yH7cXD-svhTr-9u71XJdKIZJLCgDjYFr3FFUacylxgrSXFZlp7VUsm0oqxEgxSXhFTBglGlaq05ByqvoRXZ34Gont2LyZpR-J5w04llwfiOkj0YNIHhb1ZLVtOE1YUzLVmlEteYM70-o2sT6fGBNczuCVmCjl8MJ9HTHml5s3KNoGOEU8QT4cAR493OGEMXWzd6m94v0y03ZlJzgv66NTLcytnMJpkYTlFjWBDOK6mfW1T9cqWsYjXIWOpP0k4RPhwTlXQgeupeLYyT25Sb25SaO5ZbsHw_23lgtn8z_3X8AWKfV1Q</recordid><startdate>20220823</startdate><enddate>20220823</enddate><creator>Furukawa, Soichi</creator><creator>Kobayashi, Takashi</creator><creator>Shiono, Saori</creator><creator>Nishinakagawa, Shuta</creator><general>Hindawi</general><general>John Wiley &amp; Sons, Inc</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>M7S</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-3588-8885</orcidid></search><sort><creationdate>20220823</creationdate><title>Metachronous Liver Metastasis from Alpha-Fetoprotein-Producing Gastric Cancer Successfully Treated with Capecitabine/Oxaliplatin Combination Chemotherapy</title><author>Furukawa, Soichi ; Kobayashi, Takashi ; Shiono, Saori ; Nishinakagawa, Shuta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-34ed1e7d1f306d17ad1ce7ad565fddacab93480e0c7a276e4e434d38cfce1e763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenocarcinoma</topic><topic>Antigens</topic><topic>Blood tests</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Chemotherapy</topic><topic>Drug therapy, Combination</topic><topic>Epidermal growth factor</topic><topic>Gastrectomy</topic><topic>Gastric cancer</topic><topic>Gastrointestinal surgery</topic><topic>Glycoproteins</topic><topic>Growth factors</topic><topic>Hepatectomy</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Lymph nodes</topic><topic>Lymphatic system</topic><topic>Magnetic resonance imaging</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Oxaliplatin</topic><topic>Stomach cancer</topic><topic>Tomography</topic><topic>Tumors</topic><topic>α-Fetoprotein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furukawa, Soichi</creatorcontrib><creatorcontrib>Kobayashi, Takashi</creatorcontrib><creatorcontrib>Shiono, Saori</creatorcontrib><creatorcontrib>Nishinakagawa, Shuta</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Middle East &amp; Africa Database</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Case reports in surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furukawa, Soichi</au><au>Kobayashi, Takashi</au><au>Shiono, Saori</au><au>Nishinakagawa, Shuta</au><au>Mantas, Dimitrios</au><au>Dimitrios Mantas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metachronous Liver Metastasis from Alpha-Fetoprotein-Producing Gastric Cancer Successfully Treated with Capecitabine/Oxaliplatin Combination Chemotherapy</atitle><jtitle>Case reports in surgery</jtitle><date>2022-08-23</date><risdate>2022</risdate><volume>2022</volume><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2090-6900</issn><eissn>2090-6919</eissn><abstract>A consensus regarding the treatment of recurrent alpha-fetoprotein-producing gastric carcinoma due to its rarity is lacking. We herein describe a case of such a carcinoma that was associated with metachronous liver metastasis. A 73-year-old man was referred for the surgical treatment of a type 2 gastric tumor that extended from the greater curvature of the gastric corpus to the pylorus. As no remote metastases were detected, the patient underwent open total gastrectomy with lymphadenectomy and Roux-en-Y reconstruction. Histopathological examination revealed regional lymph node metastasis and the invasion of the muscularis propria by a moderately differentiated adenocarcinoma. Immunostaining of the primary tumor was positive for alpha-fetoprotein and negative for human epidermal growth factor receptor 2. Serum alpha-fetoprotein levels decreased to within normal limits after eight courses of S-1 monotherapy; however, levels started to increase, and a hypovascular nodule in segment 5/6 of the liver was detected 3.5 years later. Serum alpha-fetoprotein levels returned to the normal range, and the tumor was undetectable after four courses of capecitabine and oxaliplatin therapy. No recurrence was detected at 1.5-year follow-up. This case demonstrates that combined capecitabine and oxaliplatin therapy can successfully treat metachronous liver metastasis from alpha-fetoprotein-producing gastric carcinoma.</abstract><cop>New York</cop><pub>Hindawi</pub><pmid>36051651</pmid><doi>10.1155/2022/2700394</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3588-8885</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2090-6900
ispartof Case reports in surgery, 2022-08, Vol.2022, p.1-9
issn 2090-6900
2090-6919
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_7b68a483978244dabcd03dd741480e6b
source PubMed (Medline); Wiley Online Library Open Access; Publicly Available Content (ProQuest)
subjects Adenocarcinoma
Antigens
Blood tests
Cancer
Cancer therapies
Care and treatment
Case Report
Case reports
Chemotherapy
Drug therapy, Combination
Epidermal growth factor
Gastrectomy
Gastric cancer
Gastrointestinal surgery
Glycoproteins
Growth factors
Hepatectomy
Liver
Liver cancer
Lymph nodes
Lymphatic system
Magnetic resonance imaging
Medical prognosis
Metastases
Metastasis
Oxaliplatin
Stomach cancer
Tomography
Tumors
α-Fetoprotein
title Metachronous Liver Metastasis from Alpha-Fetoprotein-Producing Gastric Cancer Successfully Treated with Capecitabine/Oxaliplatin Combination Chemotherapy
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T15%3A49%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metachronous%20Liver%20Metastasis%20from%20Alpha-Fetoprotein-Producing%20Gastric%20Cancer%20Successfully%20Treated%20with%20Capecitabine/Oxaliplatin%20Combination%20Chemotherapy&rft.jtitle=Case%20reports%20in%20surgery&rft.au=Furukawa,%20Soichi&rft.date=2022-08-23&rft.volume=2022&rft.spage=1&rft.epage=9&rft.pages=1-9&rft.issn=2090-6900&rft.eissn=2090-6919&rft_id=info:doi/10.1155/2022/2700394&rft_dat=%3Cgale_doaj_%3EA821430807%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c412t-34ed1e7d1f306d17ad1ce7ad565fddacab93480e0c7a276e4e434d38cfce1e763%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2709595721&rft_id=info:pmid/36051651&rft_galeid=A821430807&rfr_iscdi=true