The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study

Few studies assessed the associations between dietary vitamin K and depressive symptoms. We aimed to investigate the association between dietary vitamin K and depressive symptoms in a large cohort of North American People. In this cross-sectional analysis, 4,375 participants that were aged 45⁻79 yea...

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Bibliographic Details
Published in:Nutrients 2019-04, Vol.11 (4), p.787
Main Authors: Bolzetta, Francesco, Veronese, Nicola, Stubbs, Brendon, Noale, Marianna, Vaona, Alberto, Demurtas, Jacopo, Celotto, Stefano, Cacco, Chiara, Cester, Alberto, Caruso, Maria Gabriella, Reddavide, Rosa, Notarnicola, Maria, Maggi, Stefania, Koyanagi, Ai, Fornaro, Michele, Firth, Joseph, Smith, Lee, Solmi, Marco
Format: Article
Language:English
Subjects:
Aged
Arthritis
Cardiovascular disease
Cohort analysis
Cohort Studies
Correlation analysis
Cross-Sectional Studies
depression
Depression - etiology
Diet
Dietary intake
Female
Food
Food Analysis
Humans
Male
Mental depression
mental health
Middle Aged
Neurosciences
nutrition
Nutrition research
Older people
Osteoarthritis Initiative
Oxidative stress
Phylloquinone
Questionnaires
Regression analysis
Vitamin D
Vitamin K
Vitamin K - administration & dosage
Vitamin K Deficiency - complications
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Summary:Few studies assessed the associations between dietary vitamin K and depressive symptoms. We aimed to investigate the association between dietary vitamin K and depressive symptoms in a large cohort of North American People. In this cross-sectional analysis, 4,375 participants that were aged 45⁻79 years from the Osteoarthritis Initiative were included. Dietary vitamin K intake was collected through a semi-quantitative food frequency questionnaire and categorized in quartiles. Depressive symptoms were diagnosed using the 20-item Center for Epidemiologic Studies-Depression (CES-D) ≥ 16. To investigate the associations between vitamin K intake and depressive symptoms, logistic regression analysis were run, which adjusted for potential confounders. Overall, 437 (=10%) subjects had depressive symptoms. After adjusting for 11 confounders, people with the highest dietary vitamin K intake had lower odds of having depressive symptoms (OR = 0.58; 95%CI: 0.43⁻0.80). This effect was only present in people not taking vitamin D supplementation. In conclusion, higher dietary vitamin K intake was significantly associated with a lower presence of depressive symptoms, also after accounting for potential confounders. Future longitudinal research is required to explore the directionality of the association.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu11040787