Single high-frequency repetitive transcranial magnetic stimulation and intermittent theta pulse stimulation promote working memory behavior in participants: An event-related potential study

• Published in: Brain research bulletin 2025-01, Vol.220, p.111147, Article 111147
• Main Authors: Hu, Longting, He, Jinyan, Han, Menglin, Wang, Zhiqiang, Gao, Yulan, Zhang, Boyu, Zhou, Shuyan, Wang, Kangling, Li, Shuning, Wu, Xuan
• Format: Article
• Language: English
• Subjects: Cognitive functions; Event-related potentials; Executive functions; Transcranial magnetic stimulation; Visuospatial attention; Working memory
• ISSN: 0361-9230; 1873-2747; 1873-2747
• DOI: 10.1016/j.brainresbull.2024.111147

Repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (L-DLPFC) has an improving effect in cognitive function, but it is still not clear in what specific cognitive domains. We here combined a single session of TMS (HF-rTMS/iTBS) with electroencephalography (EEG) to clarify the effects of magnetic stimulation techniques on executive function, working memory, and visuospatial attention in healthy participants, and to investigate the underlying neurophysiological mechanisms. Fifty-one healthy participants were randomly assigned to three stimulation groups (HF-rTMS, iTBS, and sham groups). Classical psychological paradigms (task-switching, 2-back with visual Oddball) and event-related potentials (ERPs) were performed to compare the behavioral indices of each paradigm before and after the two stimulations, as well as the changes in the ERP components. Analysis of behavioral indicators showed that reaction times in the 2-back paradigm were faster after HF-rTMS and iTBS than after sham stimulation. However, no statistically significant differences were observed in the behavioral changes in the task-switching and visual Oddball paradigms. ERP analysis showed that N2 amplitude in the frontal and central regions of the participants increased during the 2-back paradigm following HF-rTMS and iTBS; however, no statistically significant differences were observed between the ERP components of the task-switching and visual Oddball paradigms. Single sessions of HF-rTMS and iTBS on the L-DLPFC specifically enhanced working memory performance, with no significant effects on executive function and visuospatial attention. Both true stimulations elicited more negative N2 in the frontal and central channels during the 2-back paradigm, suggesting increased recruitment of cognitive resources from these brain areas. Although iTBS and HF-rTMS improved working memory behavior, iTBS’s shorter stimulation time suggests it may have greater potential for clinical applications in terms of time-benefit costs. ●The combination of three cognitive paradigms with event-related potentials.●Single sessions of HF-rTMS and iTBS on the L-DLPFC enhanced working memory performance.●Both HF-rTMS and iTBS elicited more negative N2 in frontal and central parts of the brain during the 2-back paradigm.●iTBS may have greater potential for clinical applications in terms of time-benefit costs.