Prognostic value of the liver fibrosis marker fibrosis‐5 index in patients with acute heart failure

Aims Recently, liver fibrosis markers, such as the fibrosis‐4 index (FIB‐4), have been shown to be associated with prognosis in patients with heart failure. The fibrosis‐5 (FIB‐5) index, which assesses albumin, alkaline phosphatase, aspartate transaminase, alanine aminotransferase and platelet count...

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Published in:ESC Heart Failure 2022-04, Vol.9 (2), p.1380-1387
Main Authors: Maeda, Daichi, Kanzaki, Yumiko, Sakane, Kazushi, Tsuda, Kosuke, Akamatsu, Kanako, Hourai, Ryoto, Okuno, Takahiro, Tokura, Daisuke, Nakayama, Sayuri, Hasegawa, Hitomi, Morita, Hideaki, Ito, Takahide, Hoshiga, Masaaki
Format: Article
Language:English
Subjects:
Anemia
Biomarkers
Body mass index
Cardiovascular disease
Clinical outcomes
Creatinine
Ejection fraction
Enzymes
Fibrosis
Heart Failure
Hemoglobin
Hepatitis B
Hepatitis C
Humans
Ischemia
Left ventricular ejection fraction
Liver Cirrhosis - complications
Liver Cirrhosis - diagnosis
Liver diseases
Liver fibrosis
Medical prognosis
Normal distribution
Original
Peptides
Phosphatase
Prognosis
Pulmonary arteries
Stroke Volume
Values
Variables
Ventricular Function, Left
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Summary:Aims Recently, liver fibrosis markers, such as the fibrosis‐4 index (FIB‐4), have been shown to be associated with prognosis in patients with heart failure. The fibrosis‐5 (FIB‐5) index, which assesses albumin, alkaline phosphatase, aspartate transaminase, alanine aminotransferase and platelet count, is a simple liver fibrosis marker that was reported to be superior to FIB‐4 for differentiation of liver fibrosis. This study aimed to compare the prognostic value of FIB‐4 and FIB‐5 in patients with heart failure. Methods and results The FIB‐4 and FIB‐5 scores were calculated at discharge in 906 patients hospitalized with heart failure. The patients were stratified into three groups based on their FIB‐5 scores: low (n = 303), middle (n = 301), and high (n = 302) FIB‐5 groups. The primary endpoint was a composite of cardiac death or rehospitalization for heart failure. The low FIB‐5 group was older and had larger inferior vena cava diameters and higher brain natriuretic peptide levels than the other two groups. The primary endpoint occurred in 156 (51.5%), 110 (36.5%), and 54 patients (17.9%) in the low, middle, and high FIB‐5 groups, respectively (P 
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.13829