The Multifaceted Roles of Autophagy in Infectious, Obstructive, and Malignant Airway Diseases

Autophagy is a highly conserved dynamic process by which cells deliver their contents to lysosomes for degradation, thus ensuring cell homeostasis. In response to environmental stress, the induction of autophagy is crucial for cell survival. The dysregulation of this degradative process has been imp...

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Bibliographic Details
Published in:Biomedicines 2022-08, Vol.10 (8), p.1944
Main Authors: Carinci, Marianna, Palumbo, Laura, Pellielo, Giulia, Agyapong, Esther Densu, Morciano, Giampaolo, Patergnani, Simone, Giorgi, Carlotta, Pinton, Paolo, Rimessi, Alessandro
Format: Article
Language:English
Subjects:
Amino acids
Autophagy
Bronchopulmonary infection
Cell survival
Chronic obstructive pulmonary disease
Cystic fibrosis
Environmental stress
Homeostasis
Kinases
lung disease
Lung diseases
lung infectious
Lysosomes
Mammals
Membranes
Mesothelioma
Mitochondria
Mycobacterium tuberculosis
Obstructive lung disease
Pathogens
Phosphorylation
Physiological aspects
Proteins
Respiratory Syncytial Virus
Respiratory tract diseases
Review
Severe acute respiratory syndrome coronavirus 2
xenophagy SARS-CoV-2
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Summary:Autophagy is a highly conserved dynamic process by which cells deliver their contents to lysosomes for degradation, thus ensuring cell homeostasis. In response to environmental stress, the induction of autophagy is crucial for cell survival. The dysregulation of this degradative process has been implicated in a wide range of pathologies, including lung diseases, representing a relevant potential target with significant clinical outcomes. During lung disease progression and infections, autophagy may exert both protective and harmful effects on cells. In this review, we will explore the implications of autophagy and its selective forms in several lung infections, such as SARS-CoV-2, Respiratory Syncytial Virus (RSV) and Mycobacterium tuberculosis (Mtb) infections, and different lung diseases such as Cystic Fibrosis (CF), Chronic Obstructive Pulmonary Disease (COPD), and Malignant Mesothelioma (MM).
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10081944