Total flavones from Sonchus arvensis L. ameliorate colitis by adjusting the gut microbiota

• Published in: Annals of medicine (Helsinki) 2023, Vol.55 (2), p.2292246-2292246
• Main Authors: Ren, Yachao, Hou, Shenghua, He, Jing, Chang, Naidan, Zhang, Zecai, Zhou, Yulong
• Format: Article
• Language: English
• Subjects: Animals; Colitis - chemically induced; Colitis - drug therapy; Colitis - pathology; Colitis, Ulcerative - pathology; dextran sulphate sodium; Disease Models, Animal; flavones; Gastroenterology; Gastrointestinal Microbiome; gut microbiota; Humans; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S - genetics; Sonchus; Sonchus arvensis L; ulcerative colitis
• ISSN: 0785-3890; 1365-2060
• DOI: 10.1080/07853890.2023.2292246

is traditional Chinese food and medicine. We investigated protective effects of flavones from (SAF) on colitis induced by dextran sulfate sodium (DSS) in mice by regulating gut microbiota (GM). C57BL/6 mice were divided randomly: control group (CL); DSS group (ML); positive control + DSS group (AN); SAF + DSS (FE) group. The protective effects of SAF on ulcerative colitis (UC) were estimated by food intake, water intake, bodyweight loss, diarrhea, blood in stools, colon length, histology, disease activity index (DAI) score, and blood parameters. The sequencing of 16S rRNA gene was detected to investigate effect of SAF on GM. SAF attenuate bodyweight loss significantly. The DAI score was lower in FE group than that in ML group. Colon length was improved significantly in ML group. Pathologic changes could be ameliorated after SAF was administered to UC mice. SAF improved blood parameters of model mice. 16S rRNA sequencing revealed that it was very important to ameliorate colitis with bacteria of the phylum Verrucomicrobiota, class Verrucomicrobiae, order Verrucomicrobiales, family Akkermansiaceae, and genus . The SAF protective effect against colitis induced by DSS in mice may have a connection with GM diversity.