Synthesis of Interleukin-10 in Patients with Ulcerative Colitis and Helicobacter pylori Infection

Background/Aims. Epidemiological evidence suggests a relationship between Helicobacter pylori infection with the development of autoimmune diseases. H. pylori elicit a chronic systemic inflammatory response with the secretion of proinflammatory cytokines. IL-10 is a regulatory cytokine that plays a...

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Published in:Gastroenterology research and practice 2020, Vol.2020 (2020), p.1-7
Main Authors: Furuzawa-Carballeda, Janette, Barrera-Ochoa, Carlos A., Fonseca-Camarillo, G., Yamamoto-Furusho, Jesús K.
Format: Article
Language:English
Subjects:
B cells
Breath tests
Care and treatment
Cytokines
Development and progression
Endoscopy
Enzyme-linked immunosorbent assay
Epidemiology
Ethylenediaminetetraacetic acid
Health aspects
Helicobacter infections
Helicobacter pylori
Immune response
Infection
Infections
Inflammatory bowel disease
Interleukins
Laboratories
Medical research
Medicine, Experimental
Serology
Statistical analysis
Ulcerative colitis
Urea
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Summary:Background/Aims. Epidemiological evidence suggests a relationship between Helicobacter pylori infection with the development of autoimmune diseases. H. pylori elicit a chronic systemic inflammatory response with the secretion of proinflammatory cytokines. IL-10 is a regulatory cytokine that plays a central role in limiting host immune response to pathogen. Increased IL-10 levels were reported in H. pylori–infected gastric mucosa. The aim of this study was to explore the relationship between IL-10 systemic synthesis and H. pylori infection in patients with ulcerative colitis. Methods. Detection of H. pylori infection was performed by a 13C-urea breath test in 31 patients with UC. In each patient, a serum sample was drawn to measure IL-10 by the ELISA technique. Based on the primary breath test result, two groups were formed and serum IL-10 was measured. Results. Serological IL-10 levels in patients with UC and negative 13C-urea breath test was 10.28 pg/ml whereas in patients with UC and positive 13C-urea breath test was 5.5 pg/ml (P=0.035). IL-10 levels were higher in the inflammatory endoscopic and histological active groups which tested positive in the 13C-urea breath tests for H. pylori (P
ISSN:1687-6121
1687-630X
DOI:10.1155/2020/4171083