Polyphenols with Anti-Amyloid β Aggregation Show Potential Risk of Toxicity Via Pro-Oxidant Properties

• Published in: International journal of molecular sciences 2020-05, Vol.21 (10), p.3561
• Main Authors: Kobayashi, Hatasu, Murata, Mariko, Kawanishi, Shosuke, Oikawa, Shinji
• Format: Article
• Language: English
• Subjects: Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer’s Disease; Amyloid beta-Peptides - metabolism; Amyloid β; Flavonoids - chemistry; Flavonoids - toxicity; Humans; Oxidation-Reduction; Polyphenol; Polyphenols - chemistry; Polyphenols - toxicity; Pro-oxidant; Protein Aggregation, Pathological; Reactive Oxygen Species; Review
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms21103561

Alzheimer's disease (AD) is the most common form of dementia among older people. Amyloid β (Aβ) aggregation has been the focus for a therapeutic target for the treatment of AD. Naturally occurring polyphenols have an inhibitory effect on Aβ aggregation and have attracted a lot of attention for the development of treatment strategies which could mitigate the symptoms of AD. However, considerable evidence has shown that the pro-oxidant mechanisms of polyphenols could have a deleterious effect. Our group has established an assay system to evaluate the pro-oxidant characteristics of chemical compounds, based on their reactivity with DNA. In this review, we have summarized the anti-Aβ aggregation and pro-oxidant properties of polyphenols. These findings could contribute to understanding the mechanism underlying the potential risk of polyphenols. We would like to emphasize the importance of assessing the pro-oxidant properties of polyphenols from a safety point of view.