Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis

The cerebellar vermis, long associated with axial motor control, has been implicated in a surprising range of neuropsychiatric disorders and cognitive and affective functions. Remarkably little is known, however, about the specific cell types and neural circuits responsible for these diverse functio...

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Bibliographic Details
Published in:eLife 2020-07, Vol.9
Main Authors: Fujita, Hirofumi, Kodama, Takashi, du Lac, Sascha
Format: Article
Language:English
Subjects:
aarousal
aldolase c
Animals
autonomic
Autonomic nervous system
Brain
cerebellar cognitive affective syndrome
Cerebellar Nuclei - physiology
Cerebellar Vermis - physiology
Cerebellum
Circuits
Cognitive ability
Cytology
Female
Forebrain
Gene expression
Genes
Glutamatergic transmission
Male
Males
Mental disorders
Mice - physiology
Mice, Inbred C57BL
Motor Activity - physiology
Motor task performance
Nervous system diseases
Neural circuitry
Neural networks
Neurons
Neuroscience
Olivary Nucleus - physiology
Purkinje cells
Purkinje Cells - physiology
Synapses
vestibular
Vigilance
zebrin
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Summary:The cerebellar vermis, long associated with axial motor control, has been implicated in a surprising range of neuropsychiatric disorders and cognitive and affective functions. Remarkably little is known, however, about the specific cell types and neural circuits responsible for these diverse functions. Here, using single-cell gene expression profiling and anatomical circuit analyses of vermis output neurons in the mouse fastigial (medial cerebellar) nucleus, we identify five major classes of glutamatergic projection neurons distinguished by gene expression, morphology, distribution, and input-output connectivity. Each fastigial cell type is connected with a specific set of Purkinje cells and inferior olive neurons and in turn innervates a distinct collection of downstream targets. Transsynaptic tracing indicates extensive disynaptic links with cognitive, affective, and motor forebrain circuits. These results indicate that diverse cerebellar vermis functions could be mediated by modular synaptic connections of distinct fastigial cell types with posturomotor, oromotor, positional-autonomic, orienting, and vigilance circuits.
ISSN:2050-084X
2050-084X
DOI:10.7554/elife.58613