Review on recent development of quinoline for anticancer activities

Quinoline is an efficient scaffold for anticancer drug development as its derivatives have shown potent results through several mechanisms like growth regulators through “apoptosis, disruption of cell migration, inhibition of angiogenesis, modulation of nuclear receptor responsiveness and cell cycle...

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Bibliographic Details
Published in:Arabian journal of chemistry 2022-11, Vol.15 (11), p.104168, Article 104168
Main Authors: Ilakiyalakshmi, Mohan, Arumugam Napoleon, Ayyakannu
Format: Article
Language:English
Subjects:
Anticancer activity
Antiproliferative activity
Cancer
Quinolines
Synthesis
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Summary:Quinoline is an efficient scaffold for anticancer drug development as its derivatives have shown potent results through several mechanisms like growth regulators through “apoptosis, disruption of cell migration, inhibition of angiogenesis, modulation of nuclear receptor responsiveness and cell cycle arrest, etc.,” The potential of quinoline derivatives has been proved in several cancer cell lines like breast cancer, colon cancer, lung cancer, colorectal cancer, renal cancer, etc. This review article aims to provide information about the synthesis, potential of the anticancer property, cytotoxicity, and level of clinical treatments, which could lay out the research to develop more effective quinoline-derived anticancer drugs.
ISSN:1878-5352
1878-5379
DOI:10.1016/j.arabjc.2022.104168