Genetic analysis of the blood transcriptome of young healthy pigs to improve disease resilience

Disease resilience is the ability of an animal to maintain productive performance under disease conditions and is an important selection target. In pig breeding programs, disease resilience must be evaluated on selection candidates without exposing them to disease. To identify potential genetic indi...

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Bibliographic Details
Published in:Genetics selection evolution (Paris) 2023-12, Vol.55 (1), p.90-90, Article 90
Main Authors: Lim, Kyu-Sang, Cheng, Jian, Tuggle, Christopher, Dyck, Michael, Canada, PigGen, Fortin, Frederic, Harding, John, Plastow, Graham, Dekkers, Jack
Format: Article
Language:English
Subjects:
Animal husbandry
Annotations
Biological activity
Blood
Cell activation
Cellular stress response
Chromosomes
Correlation
Endoplasmic reticulum
Enrichment
Estimates
Ethylenediaminetetraacetic acid
Gene expression
Gene sequencing
Genes
Genetic analysis
Genetic aspects
Genomes
Genomics
Genotypes
Genotyping
Health aspects
Hematology
Heritability
Hogs
Immune system
Leukocytes
Liver diseases
Medical research
Medicine, Experimental
Messenger RNA
Phenotypes
Protein folding
Rankings
Resilience
RNA sequencing
RNA viruses
Severe acute respiratory syndrome coronavirus 2
Software
Swine
Transcriptomes
Viral diseases
Weaning
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Summary:Disease resilience is the ability of an animal to maintain productive performance under disease conditions and is an important selection target. In pig breeding programs, disease resilience must be evaluated on selection candidates without exposing them to disease. To identify potential genetic indicators for disease resilience that can be measured on selection candidates, we focused on the blood transcriptome of 1594 young healthy pigs with subsequent records on disease resilience. Transcriptome data were obtained by 3'mRNA sequencing and genotype data were from a 650 K genotyping array. Heritabilities of the expression of 16,545 genes were estimated, of which 5665 genes showed significant estimates of heritability (p  0.2). The correlation of heritability estimates with the corresponding estimates obtained for genes expressed in human blood was weak but a sizable number of genes with heritable expression levels overlapped. Genes with heritable expression levels were significantly enriched for biological processes such as cell activation, immune system process, stress response, and leukocyte activation, and were involved in various disease annotations such as RNA virus infection, including SARS-Cov2, as well as liver disease, and inflammation. To estimate genetic correlations with disease resilience, 3205 genotyped pigs, including the 1594 pigs with transcriptome data, were evaluated for disease resilience following their exposure to a natural polymicrobial disease challenge. Significant genetic correlations (p 
ISSN:1297-9686
0999-193X
1297-9686
DOI:10.1186/s12711-023-00860-9