Emerging Antibacterial Strategies with Application of Targeting Drug Delivery System and Combined Treatment

At present, some bacteria have developed significant resistance to almost all available antibiotics. One of the reasons that cannot be ignored is long-term exposure of bacteria to the sub-minimum inhibitory concentration (MIC) of antibiotics. Therefore, it is necessary to develop a targeted antibiot...

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Bibliographic Details
Published in:International journal of nanomedicine 2021-01, Vol.16, p.6141-6156
Main Authors: Zhang, Wenli, Hu, Enshi, Wang, Yajie, Miao, Si, Liu, Yanyan, Hu, Yumin, III, Liu, Ji, Xu, Bohui, Chen, Daquan, Shen, Yan
Format: Article
Language:English
Subjects:
Acids
Antibacterial agents
Antibiotics
antimicrobial
Antimicrobial agents
Bacteria
Bacterial infections
drug delivery
Drug delivery systems
Drug resistance
Drug resistance in microorganisms
Drugs
Enzymes
Health aspects
Infection
Infections
Microorganisms
nanocarriers
Nanoparticles
Nanotechnology
Polymers
Review
targeting strategies
Vehicles
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Summary:At present, some bacteria have developed significant resistance to almost all available antibiotics. One of the reasons that cannot be ignored is long-term exposure of bacteria to the sub-minimum inhibitory concentration (MIC) of antibiotics. Therefore, it is necessary to develop a targeted antibiotic delivery system to improve drug delivery behavior, in order to delay the generation of bacterial drug resistance. In recent years, with the continuous development of nanotechnology, various types of nanocarriers that respond to the infection microenvironment, targeting specific bacterial targets, and targeting infected cells, and so on, are gradually being used in the delivery of antibacterial agents to increase the concentration of drugs at the site of infection and reduce the side effects of drugs in normal tissues. Here, this article describes in detail the latest research progress on nanocarriers for antimicrobial, and commonly used targeted antimicrobial strategies. The advantages of the combination of nanotechnology and targeting strategies in combating bacterial infections are highlighted in this review, and the upcoming opportunities and remaining challenges in this field are rationally prospected.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S311248