Highly Variable Genomic Landscape of Endogenous Retroviruses in the C57BL/6J Inbred Strain, Depending on Individual Mouse, Gender, Organ Type, and Organ Location

Transposable repetitive elements, named the “TREome,” represent ~40% of the mouse genome. We postulate that the germ line genome undergoes temporal and spatial diversification into somatic genomes in conjunction with the TREome activity. C57BL/6J inbred mice were subjected to genomic landscape analy...

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Bibliographic Details
Published in:International journal of genomics 2017-01, Vol.2017 (2017), p.1-10
Main Authors: Cho, Kiho, Greenhalgh, David, Lim, Debora, Lee, Kang-Hoon
Format: Article
Language:English
Subjects:
Chromosomes
Deoxyribonucleic acid
DNA
Females
Genetic testing
Genetics
Genomes
Inbreeding
Kidneys
Liver
Males
Placenta
Sperm
Spleen
Studies
Thymus
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Summary:Transposable repetitive elements, named the “TREome,” represent ~40% of the mouse genome. We postulate that the germ line genome undergoes temporal and spatial diversification into somatic genomes in conjunction with the TREome activity. C57BL/6J inbred mice were subjected to genomic landscape analyses using a TREome probe from murine leukemia virus-type endogenous retroviruses (MLV-ERVs). None shared the same MLV-ERV landscape within each comparison group: (1) sperm and 18 tissues from one mouse, (2) six brain compartments from two females, (3) spleen and thymus samples from four age groups, (4) three spatial tissue sets from two females, and (5) kidney and liver samples from three females and three males. Interestingly, males had more genomic MLV-ERV copies than females; moreover, only in the males, the kidneys had higher MLV-ERV copies than the livers. Perhaps, the mouse-, gender-, and tissue/cell-dependent MLV-ERV landscapes are linked to the individual-specific and dynamic phenotypes of the C57BL/6J inbred population.
ISSN:2314-436X
2314-4378
DOI:10.1155/2017/3152410