Serum Endocan Levels Associated with Hypertension and Loss of Renal Function in Pediatric Patients after Two Years from Renal Transplant

Endocan is an important biomarker of inflammation and endothelial dysfunction that increases in association with several chronic diseases. Few published data have described the role of endocan in pediatric renal transplant (RT) patients. We evaluated the endocan concentrations in 62 children who und...

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Bibliographic Details
Published in:International Journal of Nephrology 2016-01, Vol.2016 (2016), p.32-38
Main Authors: Franco, Maria do Carmo, Feltran, Luciana de Santis, Nogueira, Paulo Cesar Koch, Huarachı, DelmaRegına Gomes, Laurindo, Aline Oliveira, Oliveira, Vanessa, Souza, Livia Victorino de, Medina-Pestana, José Osmar
Format: Article
Language:English
Subjects:
Blood pressure
Children
Chronic diseases
Cytokines
Health aspects
Hypertension
Kidneys
Medical prognosis
Medical research
Medicine, Experimental
Nephrology
Pediatrics
Studies
Transplantation
Transplants & implants
Type 2 diabetes
Urine
Variance analysis
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Summary:Endocan is an important biomarker of inflammation and endothelial dysfunction that increases in association with several chronic diseases. Few published data have described the role of endocan in pediatric renal transplant (RT) patients. We evaluated the endocan concentrations in 62 children who underwent renal transplantation and assessed their relationships with the patients’ blood pressure and loss of renal function. The endocan levels were significantly elevated in the pediatric RT patients who had hypertension and a loss of renal function. We determined positive correlations between the endocan concentrations and the hemodynamic variables (systolic blood pressure: r=0.416; P=0.001; pulse pressure: r=0.412; P=0.003). The endocan levels were inversely correlated with the estimated glomerular filtration rate (r=-0.388; P=0.003). An endocan cutoff concentration of 7.0 ng/mL identified pediatric RT patients who had hypertension and a loss of renal function with 100% sensitivity and 75% specificity. In conclusion, the endocan concentrations were significantly elevated in pediatric RT patients who had both hypertension and a loss of renal function. The correlations between the endocan levels and the hemodynamic variables and the markers of renal function strengthen the hypothesis that it is an important marker of cardiorenal risk.
ISSN:2090-2158
2090-214X
2090-2158
DOI:10.1155/2016/2180765