Defining a therapeutic range for regeneration of ischemic myocardium via shock waves

Shockwave therapy (SWT) represents a promising regenerative treatment option for patients with ischemic cardiomyopathy. Although no side-effects have been described upon SWT, potential cellular damage at therapeutic energies has not been addressed so far. In this work, we aimed to define a therapeut...

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Published in:Scientific reports 2021-01, Vol.11 (1), p.409-409, Article 409
Main Authors: Pölzl, Leo, Nägele, Felix, Hirsch, Jakob, Graber, Michael, Lobenwein, Daniela, Kirchmair, Elke, Huber, Rosalie, Dorfmüller, Christian, Lechner, Sophia, Schäfer, Georg, Hermann, Martin, Fritsch, Helga, Tancevski, Ivan, Grimm, Michael, Holfeld, Johannes, Gollmann-Tepeköylü, Can
Format: Article
Language:English
Subjects:
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AKT protein
Angiogenesis
Cardiomyopathy
Cell proliferation
Endothelial cells
Gene expression
Humanities and Social Sciences
Ischemia
multidisciplinary
Myocardium
Perfusion
Phosphorylation
Science
Science (multidisciplinary)
Shock waves
Vascularization
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Summary:Shockwave therapy (SWT) represents a promising regenerative treatment option for patients with ischemic cardiomyopathy. Although no side-effects have been described upon SWT, potential cellular damage at therapeutic energies has not been addressed so far. In this work, we aimed to define a therapeutic range for shock wave application for myocardial regeneration. We could demonstrate that SWT does not induce cellular damage beneath energy levels of 0.27 mJ/mm 2 total flux density. Endothelial cell proliferation, angiogenic gene expression and phosphorylation of AKT and ERK are enhanced in a dose dependent manner until 0.15 mJ/mm 2 energy flux density. SWT induces regeneration of ischemic muscle in vivo via expression of angiogenic gene expression, enhanced neovascularization and improved limb perfusion in a dose-dependent manner. Therefore, we provide evidence for a dose-dependent induction of angiogenesis after SWT, as well as the absence of cellular damage upon SWT within the therapeutic range. These data define for the first time a therapeutic range of SWT, a promising regenerative treatment option for ischemic cardiomyopathy.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-79776-z