Antimicrobial sesquiterpenoids from Laurencia obtusa Lamouroux

Purification of the organic extract of Lamouroux by column chromatography and preparative thin layer chromatography provided four new compounds: a eudesmane-type sesquiterpenoid [eudesma-4(15),11-diene-5,7-diol ( )], a cuparane-type sesquiterpenoid [10-hydroxycuparaldehyde ( )], and two -cuparanes [...

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Bibliographic Details
Published in:Open Chemistry 2017-01, Vol.15 (1), p.219-224
Main Authors: Bawakid, Nahed O., Alarif, Walied M., Alorfi, Hajer S., Al-Footy, Khalid O., Alburae, Najla A., Ghandourah, Mohamed A., Al-Lihaibi, Sultan S., Abdul-hameed, Zainab H.
Format: Article
Language:English
Subjects:
antimicrobial
red algae
Red Sea
Terpenoids
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Summary:Purification of the organic extract of Lamouroux by column chromatography and preparative thin layer chromatography provided four new compounds: a eudesmane-type sesquiterpenoid [eudesma-4(15),11-diene-5,7-diol ( )], a cuparane-type sesquiterpenoid [10-hydroxycuparaldehyde ( )], and two -cuparanes [3-hydroxy-15- -cuparan-10β-ol ( ) and 2-bromo-3-hydroxy-15- -cuparan-10β-ol ( )]. Structural identification was made possible by comparison of spectral data with those reported in the literature. Compounds and are significant as -cuparanes are rarely isolated from marine environment. showed moderate anticandidal activity, whereas exhibited reasonable antibacterial activity against multidrug-resistant bacteria (especially Gram-positive). All the compounds are nontoxic to
ISSN:2391-5420
2391-5420
DOI:10.1515/chem-2017-0025