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Left ventricular hypertrophy is associated with increased sirtuin level in newly diagnosed hypertensive patients

Background: Arterial hypertension is one of the leading causes of mortality and morbidity in general population. Sirtuin 1 (SIRT1) has diverse anti-inflammation, anti-oxidant, and anti-apopytosis effects on endothelium and is associated with endothelial aging and dysfunction. The objective of this s...

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Published in:Clinical and experimental hypertension (1993) 2019-08, Vol.41 (6), p.511-515
Main Authors: Duman, Hakan, Bahçeci, Ilkay, Çinier, Göksel, Duman, Handan, Bakırcı, Eftal Murat, Çetin, Mustafa
Format: Article
Language:English
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Summary:Background: Arterial hypertension is one of the leading causes of mortality and morbidity in general population. Sirtuin 1 (SIRT1) has diverse anti-inflammation, anti-oxidant, and anti-apopytosis effects on endothelium and is associated with endothelial aging and dysfunction. The objective of this study was to evaluate the relation of serum SIRT1 level with left ventricular hypertrophy (LVH) in newly diagnosed hypertensive patients. Methods: One hundered and twenty-five consecutive, newly diagnosed hypertensive patients were divided into two groups with regard to presence of LVH and compared to 40 healthy control subjects. LVH was determined by transthoracic echocardiography using the cube formula. Serum SIRT1 level was analyzed with enzyme-linked immunosorbent assay. Results: Serum SIRT1 level was significantly higher in patients with LVH compared to those without LVH (14.3 ± 3.9 ng/ml vs. 7.9 ± 3.6 ng/ml, ​P 
ISSN:1064-1963
1525-6006
DOI:10.1080/10641963.2018.1510946