Preparation of sn-2-acTAG from Polygala seed oil and a study on its hypolipidemic effect

A new class of 2-acetyl-1,3-diacyl-sn-glycerols (sn-2-acTAG) was found in the seed oil of Polygala previously. Its structure is very similar to sn-1,3-DAG, which has effect of preventing and treating hyperlipidemia and other diseases. In this study, sn-2-acTAG was enriched and confirmed, the safety...

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Bibliographic Details
Published in:Journal of functional foods 2023-12, Vol.111, p.105895, Article 105895
Main Authors: Wang, Qing, Huang, Chen, Zhang, Meng-Qi, Rong, Yao, Guo, Xu, Smith, Mark A., Liu, Chao, Sun, Jin-Yue
Format: Article
Language:English
Subjects:
class
high density lipoprotein cholesterol
high fat diet
hyperlipidemia
Hypolipidemic effect
lipemic effect
Mechanism
mechanism of action
Polygala
Polygala seed oil
rats
Sn-2-acTAG
soybean oil
Toxicity
triacylglycerols
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Summary:A new class of 2-acetyl-1,3-diacyl-sn-glycerols (sn-2-acTAG) was found in the seed oil of Polygala previously. Its structure is very similar to sn-1,3-DAG, which has effect of preventing and treating hyperlipidemia and other diseases. In this study, sn-2-acTAG was enriched and confirmed, the safety and the hypolipidemic activity was assessed. In addition the mechanism of action was investigated. Our study indicated that a diet containing 20% sn-2-acTAG or lower was not toxic to SD rats. Compared to the soybean oil group, sn-2-acTAG could lower the total cholesterol, triglyceride, and high-density lipoprotein cholesterol levels, as well as rise the level of high-density lipoprotein cholesterol. Sn-2-acTAG could regulate the expression of proinflammatory factors to ameliorate hyperlipidemia. In conclusion, sn-2-acTAG has for the first time been found to significantly ameliorate hyperlipidemia in the high-fat diet rat. This study will provide a strong theoretical support for the efficient development and application of Polygala seed oil.
ISSN:1756-4646
DOI:10.1016/j.jff.2023.105895