Hypoxia-Inducible Factor in Thyroid Carcinoma

Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/ra...

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Bibliographic Details
Published in:Journal of Thyroid Research 2011-01, Vol.2011 (2011), p.451-467
Main Authors: Burrows, Natalie, Babur, Muhammad, Resch, Julia, Williams, Kaye J., Brabant, Georg
Format: Article
Language:English
Subjects:
Gene mutations
Genetic aspects
Health aspects
Hypoxia
Physiological aspects
Review
Risk factors
Thyroid cancer
Transcription factors
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Summary:Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/radiotherapy. In addition to hypoxia, HIF-1 can be activated by growth factor-signalling pathways such as the mitogen-activated protein kinases- (MAPK-) and phosphatidylinositol-3-OH kinases- (PI3K-) signalling cascades. Mutations in these pathways are common in thyroid carcinoma and lead to enhanced HIF-1 expression and activity. Here, we summarise current data that highlights the potential role of both hypoxia and MAPK/PI3K-induced HIF-1 signalling in thyroid carcinoma progression, metastatic characteristics, and the potential role of HIF-1 in thyroid carcinoma response to radiotherapy. Direct or indirect targeting of HIF-1 using an MAPK or PI3K inhibitor in combination with radiotherapy may be a new potential therapeutic target to improve the therapeutic response of thyroid carcinoma to radiotherapy and reduce metastatic burden.
ISSN:2042-0072
2090-8067
2042-0072
DOI:10.4061/2011/762905