Identification of a new regulation pathway of EGFR and E-cadherin dynamics

E-cadherin and EGFR are known to be closely associated hence regulating differentiation and proliferation notably in epithelia. We have previously shown that galectin-7 binds to E-cadherin and favors its retention at the plasma membrane. In this study, we shed in light that galectin-7 establishes a...

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Bibliographic Details
Published in:Scientific reports 2021-11, Vol.11 (1), p.22705-22705, Article 22705
Main Authors: Proux-Gillardeaux, Veronique, Advedissian, Tamara, Perin, Charlotte, Gelly, Jean-Christophe, Viguier, Mireille, Deshayes, Frederique
Format: Article
Language:English
Subjects:
631/45
631/80
Animals
Antigens, CD - metabolism
Biochemistry
Biochemistry, Molecular Biology
Cadherins - metabolism
Cell Differentiation - genetics
Cell division
Cell Membrane - metabolism
Cell migration
Cell Movement - genetics
Cell proliferation
Cell Proliferation - genetics
Cellular Biology
E-cadherin
Epidermal growth factor
Epidermal growth factor receptors
Epidermis - metabolism
ErbB Receptors - metabolism
Female
Galectins - genetics
Galectins - metabolism
Gene Silencing
HaCaT Cells
Homeostasis
Humanities and Social Sciences
Humans
Intracellular signalling
Kinases
Life Sciences
Mice
Mice, Inbred C57BL
Mice, Knockout
Molecular Docking Simulation
multidisciplinary
Proteins
Science
Science (multidisciplinary)
Signal transduction
Signal Transduction - genetics
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Summary:E-cadherin and EGFR are known to be closely associated hence regulating differentiation and proliferation notably in epithelia. We have previously shown that galectin-7 binds to E-cadherin and favors its retention at the plasma membrane. In this study, we shed in light that galectin-7 establishes a physical link between E-cadherin and EGFR. Indeed, our results demonstrate that galectin-7 also binds to EGFR, but unlike the binding to E-cadherin this binding is sugar dependent. The establishment of E-cadherin/EGFR complex and the binding of galectin-7 to EGFR thus lead to a regulation of its signaling and intracellular trafficking allowing cell proliferation and migration control. In vivo observations further support these results since an epidermal thickening is observed in galectin-7 deficient mice. This study therefore reveals that galectin-7 controls epidermal homeostasis through the regulation of E-cadherin/EGFR balance.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-02042-3