The interplay of neuronal mitochondrial dynamics and bioenergetics: Implications for Parkinson's disease

Abstract The dynamic properties of mitochondria (mitochondrial fission, fusion, transport biogenesis and degradation) are critical for neuronal function and health, and dysregulation of mitochondrial dynamics has been increasingly linked to the pathogenesis of Parkinson's disease (PD). Mitochon...

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Bibliographic Details
Published in:Neurobiology of disease 2013-03, Vol.51, p.43-55
Main Authors: Van Laar, Victor S, Berman, Sarah B
Format: Article
Language:English
Subjects:
Alpha-synuclein
Animals
Bioenergetics
DJ-1
Energy Metabolism - physiology
Fission
Fusion
Humans
LRRK2
Mitochondria - metabolism
Mitochondria - pathology
Mitochondrial dynamics
Mitochondrial Dynamics - physiology
Mitophagy
Neurodegeneration
Neurology
Neuron
Neurons - metabolism
Neurons - pathology
Parkin
Parkinson Disease - metabolism
Parkinson Disease - pathology
Parkinson Disease - physiopathology
Parkinson's disease
PINK1
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Summary:Abstract The dynamic properties of mitochondria (mitochondrial fission, fusion, transport biogenesis and degradation) are critical for neuronal function and health, and dysregulation of mitochondrial dynamics has been increasingly linked to the pathogenesis of Parkinson's disease (PD). Mitochondrial dynamics and bioenergetics are interconnected, and this is of particular importance in neurons, which have a unique bioenergetic profile due to their energetic dependence on mitochondria and specialized, compartmentalized energetic needs. In this review, we summarize the interplay of mitochondrial dynamics and bioenergetics, and its particular relevance for neurodegeneration. Evidence linking dysregulation of mitochondrial dynamics to PD is presented from both toxin and genetic models, including newly emerging details of how PD-relevant genes PTEN-induced kinase 1 (PINK1) and Parkin regulate fission, fusion, mitophagy and transport. Finally, we discuss how neuronal bioenergetics may impact PD-relevant regulation of mitochondrial dynamics, and possible implications for understanding the role of mitochondrial dynamics in PD.
ISSN:0969-9961
1095-953X
DOI:10.1016/j.nbd.2012.05.015