Bimodal Pattern of Coronary Microvascular Involvement in Diabetes Mellitus

Background The contribution of functionally disturbed coronary autoregulation and structurally impaired microvascular vasodilatory function to reduced coronary flow velocity reserve, reflecting impaired coronary microcirculation in diabetes mellitus (DM), has not been clearly elucidated. The objecti...

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Bibliographic Details
Published in:Journal of the American Heart Association 2016-11, Vol.5 (11), p.n/a
Main Authors: Sezer, Murat, Kocaaga, Mehmet, Aslanger, Emre, Atici, Adem, Demirkiran, Ahmet, Bugra, Zehra, Umman, Sabahattin, Umman, Berrin
Format: Article
Language:English
Subjects:
Aged
Case-Control Studies
Coronary Angiography
coronary arterioles
Coronary Circulation - physiology
coronary microcirculation
coronary microvascular function
coronary microvascular resistance
Coronary Vessels
diabetes mellitus
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Diabetic Angiopathies - diagnostic imaging
Diabetic Angiopathies - etiology
Diabetic Angiopathies - physiopathology
Echocardiography, Doppler
Female
Humans
Male
Microcirculation - physiology
Microvessels
Middle Aged
Original Research
Regional Blood Flow
Time Factors
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Summary:Background The contribution of functionally disturbed coronary autoregulation and structurally impaired microvascular vasodilatory function to reduced coronary flow velocity reserve, reflecting impaired coronary microcirculation in diabetes mellitus (DM), has not been clearly elucidated. The objective of this study was to identify the mechanism of coronary microvascular impairment in DM in relation to duration of disease. Methods and Results Coronary flow velocities in the anterior descending coronary artery were assessed by transthoracic echocardiography following angiography revealing normal epicardial coronary arteries in 55 diabetic and 47 nondiabetic patients. Average peak flow velocities, coronary flow velocity reserve, and microvascular resistance in baseline and hyperemic conditions (baseline and hyperemic microvascular resistance, respectively) were assessed. Reduced coronary flow velocity reserve in patients with short duration (
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.116.003995