Sustained Consumption of a Decaffeinated Green Coffee Nutraceutical Has Limited Effects on Phenolic Metabolism and Bioavailability in Overweight/Obese Subjects

Knowledge on the bioavailability of coffee (poly)phenols mostly come from single dose postprandial studies. This study aimed at investigating the effects of regularly consuming a green coffee phenolic extract (GCPE) on the bioavailability and metabolism of (poly)phenols. Volunteers with overweight/o...

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Bibliographic Details
Published in:Nutrients 2022-06, Vol.14 (12), p.2445
Main Authors: Seguido, Miguel Ángel, Tarradas, Rosa Maria, González-Rámila, Susana, García-Cordero, Joaquín, Sarriá, Beatriz, Bravo-Clemente, Laura, Mateos, Raquel
Format: Article
Language:English
Subjects:
Acids
Bioavailability
Biological Availability
biotransformation pathways
Body weight
Coffee
Coffee - metabolism
Diet therapy
Dietary Supplements
Dihydroxybenzoic acid
Excretion
Functional foods
Functional foods & nutraceuticals
green coffee
Health aspects
Humans
hydroxycinnamates
Hydroxycinnamic acid
Metabolism
Metabolites
microbial catabolites
Microbiota
Nutrition research
Obesity
Overweight
Pharmacokinetics
Phenolic compounds
Phenols
Phenols - metabolism
Solvents
Testing
Urine
Weight control
Yogurt
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Summary:Knowledge on the bioavailability of coffee (poly)phenols mostly come from single dose postprandial studies. This study aimed at investigating the effects of regularly consuming a green coffee phenolic extract (GCPE) on the bioavailability and metabolism of (poly)phenols. Volunteers with overweight/obesity consumed a decaffeinated GCPE nutraceutical containing 300 mg hydroxycinnamates twice daily for two months. Plasma and urinary pharmacokinetics, and fecal excretion of phenolic metabolites were characterized by LC-MS-QToF at weeks 0 and 8. Fifty-four metabolites were identified in biological fluids. Regular consumption of the nutraceutical produced certain changes: reduced forms of caffeic, ferulic and coumaric acids in urine or 3-(3′-hydroxypenyl)propanoic, and 3,4-dihydroxybenzoic acids in feces significantly increased (p < 0.05) after 8 weeks; in contrast, coumaroylquinic and dihydrocoumaroylquinic acids in urine decreased (p < 0.05) compared to baseline excretion. The sum of intestinal and colonic metabolites increased after sustained consumption of GCPE, without reaching statistical significance, suggesting a small overall effect on (poly)phenols’ bioavailability.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14122445