Metabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats

The protective effects of Kisspeptin on heat-induced oxidative stress in rats were investigated by using a combination of biochemical parameters and metabonomics. Metabonomic analyses were performed using gas chromatography/mass spectrometry in conjunction with multivariate and univariate statistica...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2017-08, Vol.7 (1), p.7020-7020, Article 7020
Main Authors: Hou, Yuanlong, Wang, Xiaoyan, Ping, Jihui, Lei, Zhihai, Gao, Yingdong, Ma, Zhiyu, Jia, Cuicui, Zhang, Zheng, Li, Xiang, Jin, Mengmeng, Li, Xiaoliang, Suo, Chuan, Zhang, Ying, Su, Juan
Format: Article
Language:English
Subjects:
101/58
631/443/319/320
631/443/319/367
Animals
Disease Models, Animal
Gas chromatography
Gas Chromatography-Mass Spectrometry
Heat stress
Heat tolerance
Heat-Shock Response
Histocytochemistry
Humanities and Social Sciences
Kiss1 protein
Kisspeptins - metabolism
Liver
Liver Diseases - pathology
Mass spectrometry
Mass spectroscopy
Metabolism
Metabolomics
Microscopy, Electron
multidisciplinary
Oxidative Stress
Rats
Rodents
Science
Science (multidisciplinary)
Statistical analysis
Superoxide dismutase
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The protective effects of Kisspeptin on heat-induced oxidative stress in rats were investigated by using a combination of biochemical parameters and metabonomics. Metabonomic analyses were performed using gas chromatography/mass spectrometry in conjunction with multivariate and univariate statistical analyses. At the end point of the heat stress experiment, histological observation, ultrastructural analysis and biochemical parameters were measured. Metabonomic analysis of liver tissue revealed that Kisspeptin mainly attenuated the alteration of purine metabolism and fatty acid metabolism pathways. Futhermore, Kisspeptin also increased the levels of GSH, T-AOC as well as SOD activities, and upregulated MDA levels. These results provide important mechanistic insights into the protective effects of Kisspeptin against heat-induced oxidative stress.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-06017-1