Evaluation of cerebrovascular reactivity in moyamoya disease using oxygen-dependent magnetic resonance imaging

Moyamoya disease (MMD) is a rare cerebrovascular disorder marked by progressive stenosis of the internal carotid arteries. Assessing cerebral hemodynamics, specifically cerebrovascular reactivity (CVR), is vital for MMD management and prognosis. In this study, fMRI was performed in a prospective coh...

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Bibliographic Details
Published in:iScience 2024-02, Vol.27 (2), p.108923-108923, Article 108923
Main Authors: He, Shihao, Wang, Xilong, Niu, Hongchuan, Liu, Ziqi, Zhang, Junze, Hao, Xiaokuan, Wang, Yanru, Zhou, Zhenyu, Zhao, Yuanli, Wang, Rong
Format: Article
Language:English
Subjects:
Cardiovascular medicine
Health sciences
Internal medicine
Medical specialty
Medicine
Neurology
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Summary:Moyamoya disease (MMD) is a rare cerebrovascular disorder marked by progressive stenosis of the internal carotid arteries. Assessing cerebral hemodynamics, specifically cerebrovascular reactivity (CVR), is vital for MMD management and prognosis. In this study, fMRI was performed in a prospective cohort of 47 patients with MMD and 32 healthy controls to investigate its utility in evaluating CVR and to explore the influence of cerebral posterior circulation compensation on CVR in MMD. The regions where the CVR values of participants with MMD were lower than those of healthy controls were primarily concentrated in the frontal, parietal, and temporal lobes (p 
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2024.108923