Baru Pulp ( Dipteryx alata Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of Caenorhabditis elegans via SOD-3 and DAF-16

• Published in: Biomolecules (Basel, Switzerland) Switzerland), 2020-07, Vol.10 (8), p.1106
• Main Authors: Leite, Natasha Rios, de Araújo, Laura Costa Alves, Dos Santos da Rocha, Paola, Agarrayua, Danielle Araujo, Ávila, Daiana Silva, Carollo, Carlos Alexandre, Silva, Denise Brentan, Estevinho, Leticia Miranda, de Picoli Souza, Kely, Dos Santos, Edson Lucas
• Format: Article
• Language: English
• Subjects: Acids; Animals; Animals, Genetically Modified; antioxidant; Antioxidants; Antioxidants - isolation & purification; Antioxidants - pharmacology; Bioactive compounds; Biodiversity; Brazil; C. elegans; Caenorhabditis elegans; Caenorhabditis elegans - genetics; Caenorhabditis elegans - metabolism; Caenorhabditis elegans Proteins - genetics; Caenorhabditis elegans Proteins - metabolism; Carboxylic acids; Chlorophyll; Chromatography; Chromatography, Liquid - methods; Dipteryx - chemistry; Dipteryx alata; Ethanol; Flavonoids; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Fruit; Fruit - chemistry; fruit native; Fruits; Grassland; Health aspects; Life Expectancy; Life span; Longevity - drug effects; Mass Spectrometry - methods; Nuclear transport; nutraceutical food; Oxidative stress; Oxidative Stress - drug effects; Phenols; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; protects effects; Pulp; Savannahs; Solvents; Superoxide dismutase; Superoxide Dismutase - genetics; Superoxide Dismutase - metabolism; Terpenes; Vitamins
• ISSN: 2218-273X; 2218-273X
• DOI: 10.3390/biom10081106

Fruits are sources of bioactive compounds that are responsible for several biological activities. Therefore, this study aimed to identify the chemical composition of the pulp of the Brazilian Savanna fruit ; evaluate its toxic effects, influence on the life expectancy of the nematode , and its antioxidant activities and ; and describe the mechanisms involved. The chemical compounds identified include phenols, terpenes, fatty acid derivatives, vitamins, and a carboxylic acid. The antioxidant activity was demonstrated by radical scavenging methods. , the fruit pulp was not toxic and promoted resistance to oxidative stress in nematodes exposed to a chemical oxidizing agent. Furthermore, it promoted an increased life expectancy in wild-type nematodes and increased the expression of superoxide dismutase and the nuclear translocation of DAF-16. These results suggest that the beneficial effects identified are related to these two genes, which are involved in the regulation of metabolic activities, the control of oxidative stress, and the lifespan . These beneficial effects, which may be related to its chemical constituents, demonstrate its potential use as a functional and/or nutraceutical food.