Toxicidade e atividade antioxidante de flavonoides das cascas das raízes de Lonchocarpus filipes Toxicity and antioxidant activity of flavonoids from Lonchocarpus filipes root bark

The phytochemical investigation of dichloromethane extract from root bark of Lonchocarpus filipes Benth (Leguminosae) afforded four flavonoids including three dibenzoylmethane derivatives rarely found in nature. The structures were established based on their spectral data (¹H and 13C NMR, 2D-NMR) as...

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Bibliographic Details
Published in:Química nova 2009-01, Vol.32 (9), p.2255-2258
Main Authors: Érica L. Santos, Emmanoel V. Costa, Francisco A. Marques, Nelissa P. Vaz, Beatriz Helena L. N. Sales Maia, Eva G. Magalhães, Ana Maria A. Tozzi
Format: Article
Language:English
Subjects:
dibenzoylmethanes
flavonoids
Lonchocarpus filipes
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Summary:The phytochemical investigation of dichloromethane extract from root bark of Lonchocarpus filipes Benth (Leguminosae) afforded four flavonoids including three dibenzoylmethane derivatives rarely found in nature. The structures were established based on their spectral data (¹H and 13C NMR, 2D-NMR) as being: lanceolatin B (1), pongamol (2), (E)-7-O-methylpongamol (3) and (E)-9-O-methylpongamol (4). Compound (4) is described herein for the first time as a natural product. The extracts and the isolated compounds (1), (2) and (3) displayed high toxicity in the brine shrimp lethality assay. Only compound (2) showed antioxidant activity using a DPPH radical scavenging assay. This is the first report on the phytochemical study of Lonchocarpus filipes.
ISSN:0100-4042
1678-7064
DOI:10.1590/S0100-40422009000900002