The Multifaceted Role of Th17 Lymphocytes and Their Associated Cytokines in Cancer

While the role of T helper 17 lymphocytes (Th17) in the pathogenesis of autoimmune diseases and in infectious immunity has been relatively well defined, the impact of these cells and their associated cytokines on cancer development is still under debate. Although multiple reports have indicated that...

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Bibliographic Details
Published in:Clinical & developmental immunology 2013-01, Vol.2013 (2013), p.1-11
Main Authors: Alizadeh, Darya, Larmonier, Nicolas, Katsanis, Emmanuel
Format: Article
Language:English
Subjects:
Animals
Cancer
Cell Differentiation - immunology
Colleges & universities
Cytokines - metabolism
Humans
Immune system
Immunology
Immunotherapy
Interleukin-17 - biosynthesis
Lymphocytes
Neoplasms - immunology
Neoplasms - metabolism
Neoplasms - therapy
Review
Rodents
T cell receptors
Th17 Cells - cytology
Th17 Cells - immunology
Th17 Cells - metabolism
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Summary:While the role of T helper 17 lymphocytes (Th17) in the pathogenesis of autoimmune diseases and in infectious immunity has been relatively well defined, the impact of these cells and their associated cytokines on cancer development is still under debate. Although multiple reports have indicated that Th17 can promote anticancer immunity, others have argued that these cells may exhibit tumor-promoting properties. This dichotomy in the function of Th17 lymphocytes in cancer may be related to the versatile nature of these cells, being capable of differentiating into either proinflammatory Th1 or suppressive FoxP3-expressing Treg cells or hybrid T cell subsets depending on the underlying environmental conditions. In the current review, we examine the role of Th17 lymphocytes and Th17-associated cytokines in cancer and discuss how factors that control their final lineage commitment decision may influence the balance between their tumor-promoting versus tumor-suppressing properties.
ISSN:2314-8861
1740-2522
2314-7156
1740-2530
DOI:10.1155/2013/957878