Eco-Friendly Functionalization of Ynals with Thiols under Mild Conditions

A new eco-friendly method for the synthesis of mono- and multifunctional organosulfur compounds, based on the process between ynals and thiols, catalyzed by bulky -heterocyclic carbene (NHC), was designed and optimized. The proposed organocatalytic approach allows the straightforward formation of a...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-09, Vol.25 (17), p.9201
Main Authors: Hanek, Kamil, Żak, Patrycja
Format: Article
Language:English
Subjects:
Aldehydes
Aldehydes - chemistry
Catalysis
Efficiency
Green Chemistry Technology - methods
Ligands
Methane - analogs & derivatives
Methane - chemistry
N-heterocyclic carbene
organocatalysis
Reagents
Solvents
sulfa-Michael adduct
Sulfhydryl Compounds - chemistry
Sulfur
thioester
ynal
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Summary:A new eco-friendly method for the synthesis of mono- and multifunctional organosulfur compounds, based on the process between ynals and thiols, catalyzed by bulky -heterocyclic carbene (NHC), was designed and optimized. The proposed organocatalytic approach allows the straightforward formation of a broad range of thioesters and sulfenyl-substituted aldehydes in yields above 86%, in mild and metal-free conditions. In this study, thirty-six sulfur-based derivatives were obtained and characterized by spectroscopic methods.
ISSN:1661-6596
1422-0067
1422-0067
DOI:10.3390/ijms25179201