Role of Natural Products in Modulating Histone Deacetylases in Cancer

Histone deacetylases (HDACs) are enzymes that can control transcription by modifying chromatin conformation, molecular interactions between the DNA and the proteins as well as the histone tail, through the catalysis of the acetyl functional sites removal of proteins from the lysine residues. Also, H...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-03, Vol.24 (6), p.1047
Main Authors: Merarchi, Myriam, Sethi, Gautam, Shanmugam, Muthu K, Fan, Lu, Arfuso, Frank, Ahn, Kwang Seok
Format: Article
Language:English
Subjects:
Acetylation
Amino acids
Binding sites
Biological Products
Breast cancer
cancer
Cancer therapies
Catalysis
Cell Proliferation - drug effects
Cell Survival - drug effects
Chromatin
Conformation
Deoxyribonucleic acid
DNA
Enzymatic activity
Enzymes
Epigenetics
Federal regulation
HDACs
Histone deacetylase
Histone Deacetylase Inhibitors - chemistry
Histone Deacetylase Inhibitors - therapeutic use
Histone Deacetylases - chemistry
Histones
Humans
Kinases
Lysine
Medical prognosis
Metastases
Metastasis
Molecular interactions
Natural products
Neoplasm Metastasis
Neoplasms - drug therapy
proliferation
Prostate cancer
Proteins
Review
Transcription
Transcription factors
Tumors
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Summary:Histone deacetylases (HDACs) are enzymes that can control transcription by modifying chromatin conformation, molecular interactions between the DNA and the proteins as well as the histone tail, through the catalysis of the acetyl functional sites removal of proteins from the lysine residues. Also, HDACs have been implicated in the post transcriptional process through the regulation of the proteins acetylation, and it has been found that HDAC inhibitors (HDACi) constitute a promising class of pharmacological drugs to treat various chronic diseases, including cancer. Indeed, it has been demonstrated that in several cancers, elevated HDAC enzyme activities may be associated with aberrant proliferation, survival and metastasis. Hence, the discovery and development of novel HDACi from natural products, which are known to affect the activation of various oncogenic molecules, has attracted significant attention over the last decade. This review will briefly emphasize the potential of natural products in modifying HDAC activity and thereby attenuating initiation, progression and promotion of tumors.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24061047