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Investigation of a modified hydraulic calcium silicate-based material – Bio-C Pulpo
Abstract This study evaluated the physicochemical, biological, and antimicrobial properties of a new hydraulic calcium silicate-based modified material, and compared it with MTA Repair HP and MTA Angelus. The materials were assessed regarding color luminosity (L), color change, radiopacity, setting...
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Published in: | Brazilian oral research 2021-01, Vol.35, p.e077-e077 |
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creator | PELEPENKO, Lauter Eston SAAVEDRA, Flávia ANTUNES, Thiago Bessa Marconato BOMBARDA, Gabriela Fernanda GOMES, Brenda Paula Figueiredo de Almeida ZAIA, Alexandre Augusto MARCIANO, Marina Angélica |
description | Abstract This study evaluated the physicochemical, biological, and antimicrobial properties of a new hydraulic calcium silicate-based modified material, and compared it with MTA Repair HP and MTA Angelus. The materials were assessed regarding color luminosity (L), color change, radiopacity, setting time, and ISO 6876:2012 linear flow. Volumetric filling and volume change were evaluated using microcomputed-tomography (µCT). Chemical characterization after 28 days in Hank’s Balanced Salt Solution (HBSS) and pH analysis were also assessed. Biological characterization of cytotoxicity and microbiological assessment were also undertaken. Shapiro-Wilk, ANOVA, Levene and post hoc analyses with Bonferroni correction were performed, adopting a 5% significance level (p |
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The materials were assessed regarding color luminosity (L), color change, radiopacity, setting time, and ISO 6876:2012 linear flow. Volumetric filling and volume change were evaluated using microcomputed-tomography (µCT). Chemical characterization after 28 days in Hank’s Balanced Salt Solution (HBSS) and pH analysis were also assessed. Biological characterization of cytotoxicity and microbiological assessment were also undertaken. Shapiro-Wilk, ANOVA, Levene and post hoc analyses with Bonferroni correction were performed, adopting a 5% significance level (p <0.05). Bio-C Pulpo exhibited the highest L values after 90 days. All tested materials demonstrated color change during the analyses, and had radiopacity above 5 mm Al. MTA Repair HP set faster than Bio-C Pulpo, whereas the latter had the highest linear flow. MTA Repair HP had the highest volumetric filling in µCT analysis. Bio-C Pulpo showed the highest alkalinity during all tested periods, and the highest volumetric loss (above 9%), in comparison with MTA Repair HP and MTA Angelus. Bio-C Pulpo did not form calcium hydroxide after hydration. MTA Repair HP demonstrated the highest cytocompatibility, and Bio-C Pulpo, the highest cytotoxicity. No inhibition halos were observed for any material, and similar higher turbidity values were seen after direct contact. Composition additives used in Bio-C Pulpo modified its properties, and both the absence of calcium hydroxide deposition after hydration, and the related cytotoxicity of this material are of particular concern.</description><identifier>ISSN: 1806-8324</identifier><identifier>ISSN: 1807-3107</identifier><identifier>EISSN: 1807-3107</identifier><identifier>DOI: 10.1590/1807-3107bor-2021.vol35.0077</identifier><language>eng</language><publisher>Sociedade Brasileira de Pesquisa Odontológica - SBPqO</publisher><subject>Dental Pulp Capping ; Dentistry ; DENTISTRY, ORAL SURGERY & MEDICINE ; Endodontics</subject><ispartof>Brazilian oral research, 2021-01, Vol.35, p.e077-e077</ispartof><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-3baaa6353e3f4e836abf69323c505055c147a2260b3f8b00c8881a0b5ff224293</citedby><cites>FETCH-LOGICAL-c459t-3baaa6353e3f4e836abf69323c505055c147a2260b3f8b00c8881a0b5ff224293</cites><orcidid>0000-0001-6594-3948 ; 0000-0002-8449-0646 ; 0000-0001-8623-8543 ; 0000-0002-8365-8267 ; 0000-0003-1354-1466 ; 0000-0001-6244-2531 ; 0000-0003-3506-6985</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,24150,27924,27925</link.rule.ids></links><search><creatorcontrib>PELEPENKO, Lauter Eston</creatorcontrib><creatorcontrib>SAAVEDRA, Flávia</creatorcontrib><creatorcontrib>ANTUNES, Thiago Bessa Marconato</creatorcontrib><creatorcontrib>BOMBARDA, Gabriela Fernanda</creatorcontrib><creatorcontrib>GOMES, Brenda Paula Figueiredo de Almeida</creatorcontrib><creatorcontrib>ZAIA, Alexandre Augusto</creatorcontrib><creatorcontrib>MARCIANO, Marina Angélica</creatorcontrib><title>Investigation of a modified hydraulic calcium silicate-based material – Bio-C Pulpo</title><title>Brazilian oral research</title><addtitle>Braz. oral res</addtitle><description>Abstract This study evaluated the physicochemical, biological, and antimicrobial properties of a new hydraulic calcium silicate-based modified material, and compared it with MTA Repair HP and MTA Angelus. The materials were assessed regarding color luminosity (L), color change, radiopacity, setting time, and ISO 6876:2012 linear flow. Volumetric filling and volume change were evaluated using microcomputed-tomography (µCT). Chemical characterization after 28 days in Hank’s Balanced Salt Solution (HBSS) and pH analysis were also assessed. Biological characterization of cytotoxicity and microbiological assessment were also undertaken. Shapiro-Wilk, ANOVA, Levene and post hoc analyses with Bonferroni correction were performed, adopting a 5% significance level (p <0.05). Bio-C Pulpo exhibited the highest L values after 90 days. All tested materials demonstrated color change during the analyses, and had radiopacity above 5 mm Al. MTA Repair HP set faster than Bio-C Pulpo, whereas the latter had the highest linear flow. MTA Repair HP had the highest volumetric filling in µCT analysis. Bio-C Pulpo showed the highest alkalinity during all tested periods, and the highest volumetric loss (above 9%), in comparison with MTA Repair HP and MTA Angelus. Bio-C Pulpo did not form calcium hydroxide after hydration. MTA Repair HP demonstrated the highest cytocompatibility, and Bio-C Pulpo, the highest cytotoxicity. No inhibition halos were observed for any material, and similar higher turbidity values were seen after direct contact. Composition additives used in Bio-C Pulpo modified its properties, and both the absence of calcium hydroxide deposition after hydration, and the related cytotoxicity of this material are of particular concern.</description><subject>Dental Pulp Capping</subject><subject>Dentistry</subject><subject>DENTISTRY, ORAL SURGERY & MEDICINE</subject><subject>Endodontics</subject><issn>1806-8324</issn><issn>1807-3107</issn><issn>1807-3107</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNo9UV1rFDEUHUTBWv0P8-CDL7PefE4GfNHF6kKhBe1zuMkkNUtmsyYzhb75H_yH_hIzu6WEkJvk3HMP5zTNewIbIgb4SBT0HSPQm5Q7CpRsHlJkYgPQ9y-ai-fvl6dadopR_rp5U8oeQBIl5UVztzs8uDKHe5xDOrTJt9hOaQw-uLH99ThmXGKwrcVowzK1JdQbzq4zWCpgqmUOGNt_f_62X0Lqtu3tEo_pbfPKYyzu3dN52dxdff25_d5d33zbbT9fd5aLYe6YQUTJBHPMc6eYROPlwCizAuoSlvAeKZVgmFcGwCqlCIIR3lPK6cAum92Zd0y418ccJsyPOmHQp4eU7zXmOdjodG9xGP2IxDLFh0EOozTWKKrYIBgXsnJtzlzFBheT3qclH6p4_WP1Tq_erRYDQN1VU234cG445vR7qSbqKRTrYsSDS0vRVHCuFIheVeinM9TmVEp2_lkrAb1Gqdes9FOUep2jT1HqNUr2H_K9kUY</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>PELEPENKO, Lauter Eston</creator><creator>SAAVEDRA, Flávia</creator><creator>ANTUNES, Thiago Bessa Marconato</creator><creator>BOMBARDA, Gabriela Fernanda</creator><creator>GOMES, Brenda Paula Figueiredo de Almeida</creator><creator>ZAIA, Alexandre Augusto</creator><creator>MARCIANO, Marina Angélica</creator><general>Sociedade Brasileira de Pesquisa Odontológica - SBPqO</general><general>Sociedade Brasileira de Pesquisa Odontológica</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GPN</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6594-3948</orcidid><orcidid>https://orcid.org/0000-0002-8449-0646</orcidid><orcidid>https://orcid.org/0000-0001-8623-8543</orcidid><orcidid>https://orcid.org/0000-0002-8365-8267</orcidid><orcidid>https://orcid.org/0000-0003-1354-1466</orcidid><orcidid>https://orcid.org/0000-0001-6244-2531</orcidid><orcidid>https://orcid.org/0000-0003-3506-6985</orcidid></search><sort><creationdate>20210101</creationdate><title>Investigation of a modified hydraulic calcium silicate-based material – Bio-C Pulpo</title><author>PELEPENKO, Lauter Eston ; SAAVEDRA, Flávia ; ANTUNES, Thiago Bessa Marconato ; BOMBARDA, Gabriela Fernanda ; GOMES, Brenda Paula Figueiredo de Almeida ; ZAIA, Alexandre Augusto ; MARCIANO, Marina Angélica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-3baaa6353e3f4e836abf69323c505055c147a2260b3f8b00c8881a0b5ff224293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Dental Pulp Capping</topic><topic>Dentistry</topic><topic>DENTISTRY, ORAL SURGERY & MEDICINE</topic><topic>Endodontics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PELEPENKO, Lauter Eston</creatorcontrib><creatorcontrib>SAAVEDRA, Flávia</creatorcontrib><creatorcontrib>ANTUNES, Thiago Bessa Marconato</creatorcontrib><creatorcontrib>BOMBARDA, Gabriela Fernanda</creatorcontrib><creatorcontrib>GOMES, Brenda Paula Figueiredo de Almeida</creatorcontrib><creatorcontrib>ZAIA, Alexandre Augusto</creatorcontrib><creatorcontrib>MARCIANO, Marina Angélica</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Brazilian oral research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PELEPENKO, Lauter Eston</au><au>SAAVEDRA, Flávia</au><au>ANTUNES, Thiago Bessa Marconato</au><au>BOMBARDA, Gabriela Fernanda</au><au>GOMES, Brenda Paula Figueiredo de Almeida</au><au>ZAIA, Alexandre Augusto</au><au>MARCIANO, Marina Angélica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of a modified hydraulic calcium silicate-based material – Bio-C Pulpo</atitle><jtitle>Brazilian oral research</jtitle><addtitle>Braz. oral res</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>35</volume><spage>e077</spage><epage>e077</epage><pages>e077-e077</pages><issn>1806-8324</issn><issn>1807-3107</issn><eissn>1807-3107</eissn><abstract>Abstract This study evaluated the physicochemical, biological, and antimicrobial properties of a new hydraulic calcium silicate-based modified material, and compared it with MTA Repair HP and MTA Angelus. The materials were assessed regarding color luminosity (L), color change, radiopacity, setting time, and ISO 6876:2012 linear flow. Volumetric filling and volume change were evaluated using microcomputed-tomography (µCT). Chemical characterization after 28 days in Hank’s Balanced Salt Solution (HBSS) and pH analysis were also assessed. Biological characterization of cytotoxicity and microbiological assessment were also undertaken. Shapiro-Wilk, ANOVA, Levene and post hoc analyses with Bonferroni correction were performed, adopting a 5% significance level (p <0.05). Bio-C Pulpo exhibited the highest L values after 90 days. All tested materials demonstrated color change during the analyses, and had radiopacity above 5 mm Al. MTA Repair HP set faster than Bio-C Pulpo, whereas the latter had the highest linear flow. MTA Repair HP had the highest volumetric filling in µCT analysis. Bio-C Pulpo showed the highest alkalinity during all tested periods, and the highest volumetric loss (above 9%), in comparison with MTA Repair HP and MTA Angelus. Bio-C Pulpo did not form calcium hydroxide after hydration. MTA Repair HP demonstrated the highest cytocompatibility, and Bio-C Pulpo, the highest cytotoxicity. No inhibition halos were observed for any material, and similar higher turbidity values were seen after direct contact. 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subjects | Dental Pulp Capping Dentistry DENTISTRY, ORAL SURGERY & MEDICINE Endodontics |
title | Investigation of a modified hydraulic calcium silicate-based material – Bio-C Pulpo |
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