Loading…
Baseline Lung Allograft Dysfunction After Bilateral Lung Transplantation Is Associated With an Increased Risk of Death: Results From a Multicenter Cohort Study
A prior single-center, retrospective cohort study identified baseline lung allograft dysfunction (BLAD) as a risk factor for death in bilateral lung transplant recipients. In this multicenter prospective cohort study, we test the association of BLAD with death in bilateral lung transplant recipients...
Saved in:
Published in: | Transplantation direct 2024-07, Vol.10 (7), p.e1669 |
---|---|
Main Authors: | , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | |
---|---|
cites | cdi_FETCH-LOGICAL-c354t-fa2572f2d59077be76d7a9b8ef52fc2eb24c3b44059edf7badb21a5fc7e724fb3 |
container_end_page | |
container_issue | 7 |
container_start_page | e1669 |
container_title | Transplantation direct |
container_volume | 10 |
creator | Keller, Michael B Sun, Junfeng Alnababteh, Muhtadi Ponor, Lucia D Shah, Pali Mathew, Joby Kong, Hyesik Charya, Ananth Luikart, Helen Aryal, Shambhu Nathan, Steven D Orens, Jonathan B Khush, Kiran K Kyoo Jang, Moon Agbor-Enoh, Sean |
description | A prior single-center, retrospective cohort study identified baseline lung allograft dysfunction (BLAD) as a risk factor for death in bilateral lung transplant recipients. In this multicenter prospective cohort study, we test the association of BLAD with death in bilateral lung transplant recipients, identify clinical risk factors for BLAD, and assess its association with allograft injury on the molecular level.
This multicenter, prospective cohort study included 173 bilateral lung transplant recipients that underwent serial pulmonary function testing and plasma collection for donor-derived cell-free DNA at prespecified time points. BLAD was defined as failure to achieve ≥80% predicted for both forced expiratory volume in 1 s and forced vital capacity after lung transplant, on 2 consecutive measurements at least 3 mo apart.
BLAD was associated with increased risk of death (hazard ratio, 1.97; 95% confidence interval [CI], 1.05-3.69;
= 0.03) but not chronic lung allograft dysfunction alone (hazard ratio, 1.60; 95% CI, 0.87-2.95;
= 0.13). Recipient obesity (odds ratio, 1.69; 95% CI, 1.15-2.80;
= 0.04) and donor age (odds ratio, 1.03; 95% CI, 1.02-1.05;
= 0.004) increased the risk of developing BLAD. Patients with BLAD did not demonstrate higher log
(donor-derived cell-free DNA) levels compared with no BLAD (slope [SE]: -0.0095 [0.0007] versus -0.0109 [0.0007];
= 0.15).
BLAD is associated with an increased risk of death following lung transplantation, representing an important posttransplant outcome with valuable prognostic significance; however, early allograft specific injury on the molecular level does not increase the risk of BLAD, supporting further mechanistic insight into disease pathophysiology. |
doi_str_mv | 10.1097/TXD.0000000000001669 |
format | article |
fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_7cbc23ee4d4d424099dba7f7eda10cf5</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_7cbc23ee4d4d424099dba7f7eda10cf5</doaj_id><sourcerecordid>3074727864</sourcerecordid><originalsourceid>FETCH-LOGICAL-c354t-fa2572f2d59077be76d7a9b8ef52fc2eb24c3b44059edf7badb21a5fc7e724fb3</originalsourceid><addsrcrecordid>eNpdUsFuEzEQXSEQrUr_ACEfuaT12t51lgtKEwqRgpBKENysWXucuGzWqe1Fytf0V3GaUqXYhxmP37wZj19RvC3pRUkbebn8NbugR6us6-ZFccq45KOx5OXLI_-kOI_xdg8SdS0Yf12c8HFTccqb0-L-CiJ2rkeyGPoVmXSdXwWwicx20Q69Ts73ZGITBnLlOsgWugN0GaCP2w76BA-geSSTGL12GWTIT5fWBHK01wFzCUNuXPxNvCUzhLT-QG4wDl2K5Dr4DQHyNR-cxn5faOrXPiTyPQ1m96Z4ZaGLeP5oz4of15-W0y-jxbfP8-lkMdK8EmlkgVWSWWaqhkrZoqyNhKYdo62Y1QxbJjRvhaBVg8bKFkzLSqisliiZsC0_K-YHXuPhVm2D20DYKQ9OPQR8WCkIucMOldStZhxRmLyZoE1jWpBWooGSaltlro8Hru3QbtDsX5Wn9oz0-U3v1mrl_6iyZPkj63FmeP_IEPzdgDGpjYsauzxt9ENUnEohmRzXIkPFAaqDjzGgfapTUrXXispaUf9rJae9O-7xKemfMvhf_Qi-bQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3074727864</pqid></control><display><type>article</type><title>Baseline Lung Allograft Dysfunction After Bilateral Lung Transplantation Is Associated With an Increased Risk of Death: Results From a Multicenter Cohort Study</title><source>HEAL-Link subscriptions: Lippincott Williams & Wilkins</source><source>PubMed Central</source><creator>Keller, Michael B ; Sun, Junfeng ; Alnababteh, Muhtadi ; Ponor, Lucia ; D Shah, Pali ; Mathew, Joby ; Kong, Hyesik ; Charya, Ananth ; Luikart, Helen ; Aryal, Shambhu ; Nathan, Steven D ; Orens, Jonathan B ; Khush, Kiran K ; Kyoo Jang, Moon ; Agbor-Enoh, Sean</creator><creatorcontrib>Keller, Michael B ; Sun, Junfeng ; Alnababteh, Muhtadi ; Ponor, Lucia ; D Shah, Pali ; Mathew, Joby ; Kong, Hyesik ; Charya, Ananth ; Luikart, Helen ; Aryal, Shambhu ; Nathan, Steven D ; Orens, Jonathan B ; Khush, Kiran K ; Kyoo Jang, Moon ; Agbor-Enoh, Sean</creatorcontrib><description>A prior single-center, retrospective cohort study identified baseline lung allograft dysfunction (BLAD) as a risk factor for death in bilateral lung transplant recipients. In this multicenter prospective cohort study, we test the association of BLAD with death in bilateral lung transplant recipients, identify clinical risk factors for BLAD, and assess its association with allograft injury on the molecular level.
This multicenter, prospective cohort study included 173 bilateral lung transplant recipients that underwent serial pulmonary function testing and plasma collection for donor-derived cell-free DNA at prespecified time points. BLAD was defined as failure to achieve ≥80% predicted for both forced expiratory volume in 1 s and forced vital capacity after lung transplant, on 2 consecutive measurements at least 3 mo apart.
BLAD was associated with increased risk of death (hazard ratio, 1.97; 95% confidence interval [CI], 1.05-3.69;
= 0.03) but not chronic lung allograft dysfunction alone (hazard ratio, 1.60; 95% CI, 0.87-2.95;
= 0.13). Recipient obesity (odds ratio, 1.69; 95% CI, 1.15-2.80;
= 0.04) and donor age (odds ratio, 1.03; 95% CI, 1.02-1.05;
= 0.004) increased the risk of developing BLAD. Patients with BLAD did not demonstrate higher log
(donor-derived cell-free DNA) levels compared with no BLAD (slope [SE]: -0.0095 [0.0007] versus -0.0109 [0.0007];
= 0.15).
BLAD is associated with an increased risk of death following lung transplantation, representing an important posttransplant outcome with valuable prognostic significance; however, early allograft specific injury on the molecular level does not increase the risk of BLAD, supporting further mechanistic insight into disease pathophysiology.</description><identifier>ISSN: 2373-8731</identifier><identifier>EISSN: 2373-8731</identifier><identifier>DOI: 10.1097/TXD.0000000000001669</identifier><identifier>PMID: 38953039</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Lung Transplantation</subject><ispartof>Transplantation direct, 2024-07, Vol.10 (7), p.e1669</ispartof><rights>Copyright © 2024 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2024 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c354t-fa2572f2d59077be76d7a9b8ef52fc2eb24c3b44059edf7badb21a5fc7e724fb3</cites><orcidid>0000-0002-9380-9161</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216668/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216668/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38953039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keller, Michael B</creatorcontrib><creatorcontrib>Sun, Junfeng</creatorcontrib><creatorcontrib>Alnababteh, Muhtadi</creatorcontrib><creatorcontrib>Ponor, Lucia</creatorcontrib><creatorcontrib>D Shah, Pali</creatorcontrib><creatorcontrib>Mathew, Joby</creatorcontrib><creatorcontrib>Kong, Hyesik</creatorcontrib><creatorcontrib>Charya, Ananth</creatorcontrib><creatorcontrib>Luikart, Helen</creatorcontrib><creatorcontrib>Aryal, Shambhu</creatorcontrib><creatorcontrib>Nathan, Steven D</creatorcontrib><creatorcontrib>Orens, Jonathan B</creatorcontrib><creatorcontrib>Khush, Kiran K</creatorcontrib><creatorcontrib>Kyoo Jang, Moon</creatorcontrib><creatorcontrib>Agbor-Enoh, Sean</creatorcontrib><title>Baseline Lung Allograft Dysfunction After Bilateral Lung Transplantation Is Associated With an Increased Risk of Death: Results From a Multicenter Cohort Study</title><title>Transplantation direct</title><addtitle>Transplant Direct</addtitle><description>A prior single-center, retrospective cohort study identified baseline lung allograft dysfunction (BLAD) as a risk factor for death in bilateral lung transplant recipients. In this multicenter prospective cohort study, we test the association of BLAD with death in bilateral lung transplant recipients, identify clinical risk factors for BLAD, and assess its association with allograft injury on the molecular level.
This multicenter, prospective cohort study included 173 bilateral lung transplant recipients that underwent serial pulmonary function testing and plasma collection for donor-derived cell-free DNA at prespecified time points. BLAD was defined as failure to achieve ≥80% predicted for both forced expiratory volume in 1 s and forced vital capacity after lung transplant, on 2 consecutive measurements at least 3 mo apart.
BLAD was associated with increased risk of death (hazard ratio, 1.97; 95% confidence interval [CI], 1.05-3.69;
= 0.03) but not chronic lung allograft dysfunction alone (hazard ratio, 1.60; 95% CI, 0.87-2.95;
= 0.13). Recipient obesity (odds ratio, 1.69; 95% CI, 1.15-2.80;
= 0.04) and donor age (odds ratio, 1.03; 95% CI, 1.02-1.05;
= 0.004) increased the risk of developing BLAD. Patients with BLAD did not demonstrate higher log
(donor-derived cell-free DNA) levels compared with no BLAD (slope [SE]: -0.0095 [0.0007] versus -0.0109 [0.0007];
= 0.15).
BLAD is associated with an increased risk of death following lung transplantation, representing an important posttransplant outcome with valuable prognostic significance; however, early allograft specific injury on the molecular level does not increase the risk of BLAD, supporting further mechanistic insight into disease pathophysiology.</description><subject>Lung Transplantation</subject><issn>2373-8731</issn><issn>2373-8731</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpdUsFuEzEQXSEQrUr_ACEfuaT12t51lgtKEwqRgpBKENysWXucuGzWqe1Fytf0V3GaUqXYhxmP37wZj19RvC3pRUkbebn8NbugR6us6-ZFccq45KOx5OXLI_-kOI_xdg8SdS0Yf12c8HFTccqb0-L-CiJ2rkeyGPoVmXSdXwWwicx20Q69Ts73ZGITBnLlOsgWugN0GaCP2w76BA-geSSTGL12GWTIT5fWBHK01wFzCUNuXPxNvCUzhLT-QG4wDl2K5Dr4DQHyNR-cxn5faOrXPiTyPQ1m96Z4ZaGLeP5oz4of15-W0y-jxbfP8-lkMdK8EmlkgVWSWWaqhkrZoqyNhKYdo62Y1QxbJjRvhaBVg8bKFkzLSqisliiZsC0_K-YHXuPhVm2D20DYKQ9OPQR8WCkIucMOldStZhxRmLyZoE1jWpBWooGSaltlro8Hru3QbtDsX5Wn9oz0-U3v1mrl_6iyZPkj63FmeP_IEPzdgDGpjYsauzxt9ENUnEohmRzXIkPFAaqDjzGgfapTUrXXispaUf9rJae9O-7xKemfMvhf_Qi-bQ</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Keller, Michael B</creator><creator>Sun, Junfeng</creator><creator>Alnababteh, Muhtadi</creator><creator>Ponor, Lucia</creator><creator>D Shah, Pali</creator><creator>Mathew, Joby</creator><creator>Kong, Hyesik</creator><creator>Charya, Ananth</creator><creator>Luikart, Helen</creator><creator>Aryal, Shambhu</creator><creator>Nathan, Steven D</creator><creator>Orens, Jonathan B</creator><creator>Khush, Kiran K</creator><creator>Kyoo Jang, Moon</creator><creator>Agbor-Enoh, Sean</creator><general>Lippincott Williams & Wilkins</general><general>Wolters Kluwer</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9380-9161</orcidid></search><sort><creationdate>20240701</creationdate><title>Baseline Lung Allograft Dysfunction After Bilateral Lung Transplantation Is Associated With an Increased Risk of Death: Results From a Multicenter Cohort Study</title><author>Keller, Michael B ; Sun, Junfeng ; Alnababteh, Muhtadi ; Ponor, Lucia ; D Shah, Pali ; Mathew, Joby ; Kong, Hyesik ; Charya, Ananth ; Luikart, Helen ; Aryal, Shambhu ; Nathan, Steven D ; Orens, Jonathan B ; Khush, Kiran K ; Kyoo Jang, Moon ; Agbor-Enoh, Sean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-fa2572f2d59077be76d7a9b8ef52fc2eb24c3b44059edf7badb21a5fc7e724fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Lung Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keller, Michael B</creatorcontrib><creatorcontrib>Sun, Junfeng</creatorcontrib><creatorcontrib>Alnababteh, Muhtadi</creatorcontrib><creatorcontrib>Ponor, Lucia</creatorcontrib><creatorcontrib>D Shah, Pali</creatorcontrib><creatorcontrib>Mathew, Joby</creatorcontrib><creatorcontrib>Kong, Hyesik</creatorcontrib><creatorcontrib>Charya, Ananth</creatorcontrib><creatorcontrib>Luikart, Helen</creatorcontrib><creatorcontrib>Aryal, Shambhu</creatorcontrib><creatorcontrib>Nathan, Steven D</creatorcontrib><creatorcontrib>Orens, Jonathan B</creatorcontrib><creatorcontrib>Khush, Kiran K</creatorcontrib><creatorcontrib>Kyoo Jang, Moon</creatorcontrib><creatorcontrib>Agbor-Enoh, Sean</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Transplantation direct</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keller, Michael B</au><au>Sun, Junfeng</au><au>Alnababteh, Muhtadi</au><au>Ponor, Lucia</au><au>D Shah, Pali</au><au>Mathew, Joby</au><au>Kong, Hyesik</au><au>Charya, Ananth</au><au>Luikart, Helen</au><au>Aryal, Shambhu</au><au>Nathan, Steven D</au><au>Orens, Jonathan B</au><au>Khush, Kiran K</au><au>Kyoo Jang, Moon</au><au>Agbor-Enoh, Sean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Baseline Lung Allograft Dysfunction After Bilateral Lung Transplantation Is Associated With an Increased Risk of Death: Results From a Multicenter Cohort Study</atitle><jtitle>Transplantation direct</jtitle><addtitle>Transplant Direct</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>10</volume><issue>7</issue><spage>e1669</spage><pages>e1669-</pages><issn>2373-8731</issn><eissn>2373-8731</eissn><abstract>A prior single-center, retrospective cohort study identified baseline lung allograft dysfunction (BLAD) as a risk factor for death in bilateral lung transplant recipients. In this multicenter prospective cohort study, we test the association of BLAD with death in bilateral lung transplant recipients, identify clinical risk factors for BLAD, and assess its association with allograft injury on the molecular level.
This multicenter, prospective cohort study included 173 bilateral lung transplant recipients that underwent serial pulmonary function testing and plasma collection for donor-derived cell-free DNA at prespecified time points. BLAD was defined as failure to achieve ≥80% predicted for both forced expiratory volume in 1 s and forced vital capacity after lung transplant, on 2 consecutive measurements at least 3 mo apart.
BLAD was associated with increased risk of death (hazard ratio, 1.97; 95% confidence interval [CI], 1.05-3.69;
= 0.03) but not chronic lung allograft dysfunction alone (hazard ratio, 1.60; 95% CI, 0.87-2.95;
= 0.13). Recipient obesity (odds ratio, 1.69; 95% CI, 1.15-2.80;
= 0.04) and donor age (odds ratio, 1.03; 95% CI, 1.02-1.05;
= 0.004) increased the risk of developing BLAD. Patients with BLAD did not demonstrate higher log
(donor-derived cell-free DNA) levels compared with no BLAD (slope [SE]: -0.0095 [0.0007] versus -0.0109 [0.0007];
= 0.15).
BLAD is associated with an increased risk of death following lung transplantation, representing an important posttransplant outcome with valuable prognostic significance; however, early allograft specific injury on the molecular level does not increase the risk of BLAD, supporting further mechanistic insight into disease pathophysiology.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>38953039</pmid><doi>10.1097/TXD.0000000000001669</doi><orcidid>https://orcid.org/0000-0002-9380-9161</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2373-8731 |
ispartof | Transplantation direct, 2024-07, Vol.10 (7), p.e1669 |
issn | 2373-8731 2373-8731 |
language | eng |
recordid | cdi_doaj_primary_oai_doaj_org_article_7cbc23ee4d4d424099dba7f7eda10cf5 |
source | HEAL-Link subscriptions: Lippincott Williams & Wilkins; PubMed Central |
subjects | Lung Transplantation |
title | Baseline Lung Allograft Dysfunction After Bilateral Lung Transplantation Is Associated With an Increased Risk of Death: Results From a Multicenter Cohort Study |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T17%3A10%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Baseline%20Lung%20Allograft%20Dysfunction%20After%20Bilateral%20Lung%20Transplantation%20Is%20Associated%20With%20an%20Increased%20Risk%20of%20Death:%20Results%20From%20a%20Multicenter%20Cohort%20Study&rft.jtitle=Transplantation%20direct&rft.au=Keller,%20Michael%20B&rft.date=2024-07-01&rft.volume=10&rft.issue=7&rft.spage=e1669&rft.pages=e1669-&rft.issn=2373-8731&rft.eissn=2373-8731&rft_id=info:doi/10.1097/TXD.0000000000001669&rft_dat=%3Cproquest_doaj_%3E3074727864%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c354t-fa2572f2d59077be76d7a9b8ef52fc2eb24c3b44059edf7badb21a5fc7e724fb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3074727864&rft_id=info:pmid/38953039&rfr_iscdi=true |