Rapid remodeling observed at mid-term in-vivo study of a smart reinforced acellular vascular graft implanted on a rat model

The poor performance of conventional techniques used in cardiovascular disease patients requiring hemodialysis or arterial bypass grafting has prompted tissue engineers to search for clinically appropriate off-the-shelf vascular grafts. Most patients with cardiovascular disease lack suitable autolog...

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Bibliographic Details
Published in:Journal of biological engineering 2023-01, Vol.17 (1), p.1-1, Article 1
Main Authors: Obiweluozor, Francis O, Kayumov, Mukhammad, Kwak, Yujin, Cho, Hwa-Jin, Park, Chan-Hee, Park, Jun-Kyu, Jeong, Yun-Jin, Lee, Dong-Weon, Kim, Do-Wan, Jeong, In-Seok
Format: Article
Language:English
Subjects:
3D printing
Blood clot
Coronary artery bypass
Elastin
Electrospinning
Medium-term performance
Nanofibers
Thrombosis
Tissue regeneration
Transplantation of organs, tissues, etc
Vascular graft
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Summary:The poor performance of conventional techniques used in cardiovascular disease patients requiring hemodialysis or arterial bypass grafting has prompted tissue engineers to search for clinically appropriate off-the-shelf vascular grafts. Most patients with cardiovascular disease lack suitable autologous tissue because of age or previous surgery. Commercially available vascular grafts with diameters of  1.5 years) in large animals with a vasculature similar to humans are needed.
ISSN:1754-1611
1754-1611
DOI:10.1186/s13036-022-00313-9