Effect of a lead block on alveolar bone protection in image-guided high-dose-rate interstitial brachytherapy for tongue cancer: using model-based dose calculation algorithms to correct for inhomogeneity

• Published in: Journal of contemporary brachytherapy 2022-01, Vol.14 (1), p.87-95
• Main Authors: Akiyama, Hironori, Yoshida, Ken, Takenaka, Tadashi, Kotsuma, Tadayuki, Masui, Koji, Monzen, Hajime, Sumida, Iori, Tsujimoto, Yutaka, Miyao, Mamoru, Okumura, Hiroki, Shimbo, Taiju, Takegawa, Hideki, Murakami, Naoya, Inaba, Koji, Kashihara, Tairo, Takácsi-Nagy, Zoltán, Tselis, Nikolaos, Yamazaki, Hideya, Tanaka, Eiichi, Nihei, Keiji, Ariji, Yoshiko
• Format: Article
• Language: English
• Subjects: Algorithms; bone protection; brachytherapy; Cancer; Formalism; Fractions; Histograms; Inhomogeneity; inhomogeneity correction; lead block; Medical imaging; Oral cancer; Original Paper; Parameters; Radiation dosage; Radiation therapy; Silicon; Thickness; Tongue; tongue cancer
• ISSN: 1689-832X; 2081-2841
• DOI: 10.5114/jcb.2022.113232

The purpose of this study was to evaluate the effect of a lead block for alveolar bone protection in image-guided high-dose-rate interstitial brachytherapy for tongue cancer. We treated 6 patients and delivered 5,400 cGy in 9 fractions using a lead block. Effects of lead block (median thickness, 4 mm) on dose attenuation by distance were visually examined using TG-43 formalism-based dose distribution curves to determine whether or not the area with the highest dose is located in the alveolar bone, where there is a high-risk of infection. Dose re-calculations were performed using TG-186 formalism with advanced collapsed cone engine (ACE) for inhomogeneity correction set to cortical bone density for the whole mandible and alveolar bone, water density for clinical target volume (CTV), air density for outside body and lead density, and silastic density for lead block and its' silicon replica, respectively. The highest dose was detected outside the alveolar bone in five of the six cases. For dose-volume histogram analysis, median minimum doses delivered per fraction to the 0.1 cm of alveolar bone (D0.1cm ) were 344.3 (range, 262.9-427.4) cGy, 336.6 (253.3-425.0) cGy, and 169.7 (114.9-233.3) cGy, respectively. D0.1cm was significantly lower than other parameters. No significant difference was observed between CTV-related parameters. The results suggested that using a lead block for alveolar bone protection with a thickness of about 4 mm, can shift the highest dose area to non-alveolar regions. In addition, it reduced D0.1cm of alveolar bone to about half, without affecting tumor dose.