Emerging Biomedical and Clinical Applications of 3D-Printed Poly(Lactic Acid)-Based Devices and Delivery Systems

Poly(lactic acid) (PLA) is widely used in the field of medicine due to its biocompatibility, versatility, and cost-effectiveness. Three-dimensional (3D) printing or the systematic deposition of PLA in layers has enabled the fabrication of customized scaffolds for various biomedical and clinical appl...

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Bibliographic Details
Published in:Bioengineering (Basel) 2024-07, Vol.11 (7), p.705
Main Authors: Barcena, Allan John R, Ravi, Prashanth, Kundu, Suprateek, Tappa, Karthik
Format: Article
Language:English
Subjects:
3-D printers
3D printing
Acids
Antibiotics
Antihypertensives
Antiviral agents
Biocompatibility
Biomedical engineering
Bones
Composite materials
Controlled release
Cost effectiveness
Dosimetry
Drug delivery
Drug delivery systems
Growth factors
Hormones
medical device
Medical device industry
Medical equipment
Medical innovations
Patients
Polylactic acid
Polymers
Prostheses
Prosthetics
Radiation therapy
Reagents
Regenerative medicine
Scaffolds
Simulators
surgery
Surgical apparatus & instruments
Surgical instruments
Therapeutic applications
Tissue engineering
Versatility
Vitamins
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Summary:Poly(lactic acid) (PLA) is widely used in the field of medicine due to its biocompatibility, versatility, and cost-effectiveness. Three-dimensional (3D) printing or the systematic deposition of PLA in layers has enabled the fabrication of customized scaffolds for various biomedical and clinical applications. In tissue engineering and regenerative medicine, 3D-printed PLA has been mostly used to generate bone tissue scaffolds, typically in combination with different polymers and ceramics. PLA's versatility has also allowed the development of drug-eluting constructs for the controlled release of various agents, such as antibiotics, antivirals, anti-hypertensives, chemotherapeutics, hormones, and vitamins. Additionally, 3D-printed PLA has recently been used to develop diagnostic electrodes, prostheses, orthoses, surgical instruments, and radiotherapy devices. PLA has provided a cost-effective, accessible, and safer means of improving patient care through surgical and dosimetry guides, as well as enhancing medical education through training models and simulators. Overall, the widespread use of 3D-printed PLA in biomedical and clinical settings is expected to persistently stimulate biomedical innovation and revolutionize patient care and healthcare delivery.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering11070705