Potential Anti-SARS-CoV-2 Prodrugs Activated by Phosphorylation and Their Role in the Aged Population

The COVID-19 pandemic has flared across every part of the globe and affected populations from different age groups differently. People aged from 40 to 80 years or older are at an increased risk of morbidity and mortality due to COVID-19. Therefore, there is an urgent requirement to develop therapeut...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-03, Vol.28 (5), p.2332
Main Authors: Chavda, Vivek P, Teli, Divya, Balar, Pankti C, Vaghela, Dixa, Solanki, Hetvi K, Vaishnav, Akta, Vora, Lalitkumar
Format: Article
Language:English
Subjects:
2-Deoxy-D-glucose (2-DG)
Acids
Adenosine
aged population
Animal models
Animals
Antiviral Agents - therapeutic use
Antiviral drugs
Clinical trials
Coronaviruses
COVID-19
COVID-19 vaccines
Dextrose
Drug delivery
Drug delivery systems
Drugs
Enzymes
Epidemics
favipiravir
Glucose
Health aspects
Health risks
Humans
India
Medical research
Medicine, Experimental
molnupiravir
Morbidity
Pandemics
Pharmacokinetics
Phosphorylation
prodrug
Prodrugs
Reagents
remdesivir
Review
RNA polymerase
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Toxicity
Vehicles
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Summary:The COVID-19 pandemic has flared across every part of the globe and affected populations from different age groups differently. People aged from 40 to 80 years or older are at an increased risk of morbidity and mortality due to COVID-19. Therefore, there is an urgent requirement to develop therapeutics to decrease the risk of the disease in the aged population. Over the last few years, several prodrugs have demonstrated significant anti-SARS-CoV-2 effects in in vitro assays, animal models, and medical practice. Prodrugs are used to enhance drug delivery by improving pharmacokinetic parameters, decreasing toxicity, and attaining site specificity. This article discusses recently explored prodrugs such as remdesivir, molnupiravir, favipiravir, and 2-deoxy-D-glucose (2-DG) and their implications in the aged population, as well as investigating recent clinical trials.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28052332