The role of HIV Tat protein in HIV-related cardiovascular diseases

The human immunodeficiency virus (HIV) is a major global public health issue. HIV-related cardiovascular disease remains a leading cause of morbidity and mortality in HIV positive patients. HIV Tat is a regulatory protein encoded by tat gene of HIV-1, which not only promotes the transcription of HIV...

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Bibliographic Details
Published in:Journal of translational medicine 2018-05, Vol.16 (1), p.121-121, Article 121
Main Authors: Jiang, Yanan, Chai, Lu, Fasae, Moyondafoluwa Blessing, Bai, Yunlong
Format: Article
Language:English
Subjects:
Analysis
Cardiovascular diseases
Complications and side effects
Genetic aspects
Genetic transcription
HIV
HIV infection
Public health
Review
Risk factors
Tat
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Summary:The human immunodeficiency virus (HIV) is a major global public health issue. HIV-related cardiovascular disease remains a leading cause of morbidity and mortality in HIV positive patients. HIV Tat is a regulatory protein encoded by tat gene of HIV-1, which not only promotes the transcription of HIV, but it is also involved in the pathogenesis of HIV-related complications. This review is aimed at summarizing the current understanding of Tat in HIV-related cardiovascular diseases.
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-018-1500-0