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Diagnosis of inflammatory peri-implant diseases using an immunochromatographic assay for calprotectin in peri-implant crevicular fluid
Background The incidence rate of peri-implant diseases is increasing with implant placement. Early detection of peri-implant diseases is important to prevent and treat these diseases, and a simple and objective diagnostic method is expected. Immunochromatographic (IC) assays are used for rapid diagn...
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| Published in: | International journal of implant dentistry 2021-10, Vol.7 (1), p.106-106, Article 106 |
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| container_end_page | 106 |
| container_issue | 1 |
| container_start_page | 106 |
| container_title | International journal of implant dentistry |
| container_volume | 7 |
| creator | Kido, Rie Kido, Jun-ichi Nishikawa, Yasufumi Sakamoto, Eijiro Tomotake, Yoritoki Yumoto, Hiromichi |
| description | Background
The incidence rate of peri-implant diseases is increasing with implant placement. Early detection of peri-implant diseases is important to prevent and treat these diseases, and a simple and objective diagnostic method is expected. Immunochromatographic (IC) assays are used for rapid diagnostic methods for some diseases. The aim of this clinical study was to determine the amount of calprotectin, an inflammatory marker, in peri-implant crevicular fluid (PICF) using an IC chip, and estimate the possibility of this diagnostic system.
Methods
Forty-six individuals with dental implants participated in a pilot study. PICF samples were collected from the peri-implant sites with or without inflammation after clinical examinations including probing depth (PD), bleeding on probing (BOP) and gingival index (GI). Calprotectin in PICF was determined by an IC chip and enzyme-linked immunosorbent assay (ELISA) for calprotectin. The density of calprotectin line on the IC chip was measured using an IC reader (IC reader value). The relationship between IC reader value and ELISA value or clinical parameters was investigated. A receiver operating characteristic (ROC) curve analysis of IC reader value of calprotectin was performed to predict inflammation in peri-implant diseases.
Results
IC reader value of calprotectin was significantly correlated with its ELISA value and PD. IC reader values of calprotectin in PICF samples from periodontal sites with GI-1 and GI-2, and with BOP-positive sites were significantly higher than those of PICF samples from GI-0 sites, and BOP-negative sites, respectively. The IC reader value for calprotectin in PICF samples from inflammatory diseased sites was significantly higher than that of non-diseased sites. ROC analysis suggested that the IC reader value of PICF calprotectin was useful for predicting inflammatory peri-implant diseases.
Conclusion
IC assay for PICF calprotectin may be a possible system for diagnosing the inflammatory peri-implant diseases. |
| doi_str_mv | 10.1186/s40729-021-00386-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_7ce3f96260db40f89980219a3c37a9be</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_7ce3f96260db40f89980219a3c37a9be</doaj_id><sourcerecordid>2580186282</sourcerecordid><originalsourceid>FETCH-LOGICAL-c514t-103a5bf71304db156459d56a5f33724914aebd78e8119eb304588425a657f5fa3</originalsourceid><addsrcrecordid>eNp9ks9u1DAQhyMEolXpC3CyxIVLiv8m9gUJFSiVKnGBszVx7KxXiR3spNL2AXhu3E0FLAdOtuxvPs2MflX1muArQmTzLnPcUlVjSmqMmWzqh2fVOSVK1hwz_vyv-1l1mfMeY0waxiklL6szxhvKBBfn1c-PHoYQs88oOuSDG2GaYInpgGabfO2neYSwoN5nC9lmtGYfBgQB-WlaQzS7FB_5IcG88wZBznBALiZkYJxTXKxZfIHDqc4ke-_NOkJCblx9_6p64WDM9vLpvKi-f_707fpLfff15vb6w11tBOFLTTAD0bmWMMz7joiGC9WLBoRjrKVcEQ6261tpJSHKdoUSUnIqoBGtEw7YRXW7efsIez0nP0E66AheHx9iGjSkxZvR6tZY5lRDG9x3HDuplCzLVsAMa0F1trjeb6557SbbGxuWBOOJ9PQn-J0e4r2WXMlWiCJ4-yRI8cdq86Inn40dy4ZsXLOmQuJGiTJWQd_8g-7jmkJZ1ZEqgaCSFopulEkx52Td72YI1o-p0VtqdBlEH1OjH0oR24pygcNg0x_1f6p-ATedxq4</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2580186282</pqid></control><display><type>article</type><title>Diagnosis of inflammatory peri-implant diseases using an immunochromatographic assay for calprotectin in peri-implant crevicular fluid</title><source>Publicly Available Content Database</source><source>Springer Nature - SpringerLink Journals - Fully Open Access</source><source>PubMed Central</source><source>Coronavirus Research Database</source><creator>Kido, Rie ; Kido, Jun-ichi ; Nishikawa, Yasufumi ; Sakamoto, Eijiro ; Tomotake, Yoritoki ; Yumoto, Hiromichi</creator><creatorcontrib>Kido, Rie ; Kido, Jun-ichi ; Nishikawa, Yasufumi ; Sakamoto, Eijiro ; Tomotake, Yoritoki ; Yumoto, Hiromichi</creatorcontrib><description>Background
The incidence rate of peri-implant diseases is increasing with implant placement. Early detection of peri-implant diseases is important to prevent and treat these diseases, and a simple and objective diagnostic method is expected. Immunochromatographic (IC) assays are used for rapid diagnostic methods for some diseases. The aim of this clinical study was to determine the amount of calprotectin, an inflammatory marker, in peri-implant crevicular fluid (PICF) using an IC chip, and estimate the possibility of this diagnostic system.
Methods
Forty-six individuals with dental implants participated in a pilot study. PICF samples were collected from the peri-implant sites with or without inflammation after clinical examinations including probing depth (PD), bleeding on probing (BOP) and gingival index (GI). Calprotectin in PICF was determined by an IC chip and enzyme-linked immunosorbent assay (ELISA) for calprotectin. The density of calprotectin line on the IC chip was measured using an IC reader (IC reader value). The relationship between IC reader value and ELISA value or clinical parameters was investigated. A receiver operating characteristic (ROC) curve analysis of IC reader value of calprotectin was performed to predict inflammation in peri-implant diseases.
Results
IC reader value of calprotectin was significantly correlated with its ELISA value and PD. IC reader values of calprotectin in PICF samples from periodontal sites with GI-1 and GI-2, and with BOP-positive sites were significantly higher than those of PICF samples from GI-0 sites, and BOP-negative sites, respectively. The IC reader value for calprotectin in PICF samples from inflammatory diseased sites was significantly higher than that of non-diseased sites. ROC analysis suggested that the IC reader value of PICF calprotectin was useful for predicting inflammatory peri-implant diseases.
Conclusion
IC assay for PICF calprotectin may be a possible system for diagnosing the inflammatory peri-implant diseases.</description><identifier>ISSN: 2198-4034</identifier><identifier>EISSN: 2198-4034</identifier><identifier>DOI: 10.1186/s40729-021-00386-z</identifier><identifier>PMID: 34623545</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Assaying ; Calprotectin ; Dental implants ; Dentistry ; Diagnosis ; Diagnostic systems ; Immunochromatographic assay ; Integrated circuits ; Medicine ; Peri-implant crevicular fluid ; Peri-implant diseases ; Transplants & implants</subject><ispartof>International journal of implant dentistry, 2021-10, Vol.7 (1), p.106-106, Article 106</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-103a5bf71304db156459d56a5f33724914aebd78e8119eb304588425a657f5fa3</citedby><cites>FETCH-LOGICAL-c514t-103a5bf71304db156459d56a5f33724914aebd78e8119eb304588425a657f5fa3</cites><orcidid>0000-0002-3949-5931</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498755/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2580186282?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,38495,43874,44569,53769,53771</link.rule.ids></links><search><creatorcontrib>Kido, Rie</creatorcontrib><creatorcontrib>Kido, Jun-ichi</creatorcontrib><creatorcontrib>Nishikawa, Yasufumi</creatorcontrib><creatorcontrib>Sakamoto, Eijiro</creatorcontrib><creatorcontrib>Tomotake, Yoritoki</creatorcontrib><creatorcontrib>Yumoto, Hiromichi</creatorcontrib><title>Diagnosis of inflammatory peri-implant diseases using an immunochromatographic assay for calprotectin in peri-implant crevicular fluid</title><title>International journal of implant dentistry</title><addtitle>Int J Implant Dent</addtitle><description>Background
The incidence rate of peri-implant diseases is increasing with implant placement. Early detection of peri-implant diseases is important to prevent and treat these diseases, and a simple and objective diagnostic method is expected. Immunochromatographic (IC) assays are used for rapid diagnostic methods for some diseases. The aim of this clinical study was to determine the amount of calprotectin, an inflammatory marker, in peri-implant crevicular fluid (PICF) using an IC chip, and estimate the possibility of this diagnostic system.
Methods
Forty-six individuals with dental implants participated in a pilot study. PICF samples were collected from the peri-implant sites with or without inflammation after clinical examinations including probing depth (PD), bleeding on probing (BOP) and gingival index (GI). Calprotectin in PICF was determined by an IC chip and enzyme-linked immunosorbent assay (ELISA) for calprotectin. The density of calprotectin line on the IC chip was measured using an IC reader (IC reader value). The relationship between IC reader value and ELISA value or clinical parameters was investigated. A receiver operating characteristic (ROC) curve analysis of IC reader value of calprotectin was performed to predict inflammation in peri-implant diseases.
Results
IC reader value of calprotectin was significantly correlated with its ELISA value and PD. IC reader values of calprotectin in PICF samples from periodontal sites with GI-1 and GI-2, and with BOP-positive sites were significantly higher than those of PICF samples from GI-0 sites, and BOP-negative sites, respectively. The IC reader value for calprotectin in PICF samples from inflammatory diseased sites was significantly higher than that of non-diseased sites. ROC analysis suggested that the IC reader value of PICF calprotectin was useful for predicting inflammatory peri-implant diseases.
Conclusion
IC assay for PICF calprotectin may be a possible system for diagnosing the inflammatory peri-implant diseases.</description><subject>Assaying</subject><subject>Calprotectin</subject><subject>Dental implants</subject><subject>Dentistry</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Immunochromatographic assay</subject><subject>Integrated circuits</subject><subject>Medicine</subject><subject>Peri-implant crevicular fluid</subject><subject>Peri-implant diseases</subject><subject>Transplants & implants</subject><issn>2198-4034</issn><issn>2198-4034</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>COVID</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9ks9u1DAQhyMEolXpC3CyxIVLiv8m9gUJFSiVKnGBszVx7KxXiR3spNL2AXhu3E0FLAdOtuxvPs2MflX1muArQmTzLnPcUlVjSmqMmWzqh2fVOSVK1hwz_vyv-1l1mfMeY0waxiklL6szxhvKBBfn1c-PHoYQs88oOuSDG2GaYInpgGabfO2neYSwoN5nC9lmtGYfBgQB-WlaQzS7FB_5IcG88wZBznBALiZkYJxTXKxZfIHDqc4ke-_NOkJCblx9_6p64WDM9vLpvKi-f_707fpLfff15vb6w11tBOFLTTAD0bmWMMz7joiGC9WLBoRjrKVcEQ6261tpJSHKdoUSUnIqoBGtEw7YRXW7efsIez0nP0E66AheHx9iGjSkxZvR6tZY5lRDG9x3HDuplCzLVsAMa0F1trjeb6557SbbGxuWBOOJ9PQn-J0e4r2WXMlWiCJ4-yRI8cdq86Inn40dy4ZsXLOmQuJGiTJWQd_8g-7jmkJZ1ZEqgaCSFopulEkx52Td72YI1o-p0VtqdBlEH1OjH0oR24pygcNg0x_1f6p-ATedxq4</recordid><startdate>20211008</startdate><enddate>20211008</enddate><creator>Kido, Rie</creator><creator>Kido, Jun-ichi</creator><creator>Nishikawa, Yasufumi</creator><creator>Sakamoto, Eijiro</creator><creator>Tomotake, Yoritoki</creator><creator>Yumoto, Hiromichi</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>COVID</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>M0S</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-3949-5931</orcidid></search><sort><creationdate>20211008</creationdate><title>Diagnosis of inflammatory peri-implant diseases using an immunochromatographic assay for calprotectin in peri-implant crevicular fluid</title><author>Kido, Rie ; Kido, Jun-ichi ; Nishikawa, Yasufumi ; Sakamoto, Eijiro ; Tomotake, Yoritoki ; Yumoto, Hiromichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-103a5bf71304db156459d56a5f33724914aebd78e8119eb304588425a657f5fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Assaying</topic><topic>Calprotectin</topic><topic>Dental implants</topic><topic>Dentistry</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Immunochromatographic assay</topic><topic>Integrated circuits</topic><topic>Medicine</topic><topic>Peri-implant crevicular fluid</topic><topic>Peri-implant diseases</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kido, Rie</creatorcontrib><creatorcontrib>Kido, Jun-ichi</creatorcontrib><creatorcontrib>Nishikawa, Yasufumi</creatorcontrib><creatorcontrib>Sakamoto, Eijiro</creatorcontrib><creatorcontrib>Tomotake, Yoritoki</creatorcontrib><creatorcontrib>Yumoto, Hiromichi</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of implant dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kido, Rie</au><au>Kido, Jun-ichi</au><au>Nishikawa, Yasufumi</au><au>Sakamoto, Eijiro</au><au>Tomotake, Yoritoki</au><au>Yumoto, Hiromichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnosis of inflammatory peri-implant diseases using an immunochromatographic assay for calprotectin in peri-implant crevicular fluid</atitle><jtitle>International journal of implant dentistry</jtitle><stitle>Int J Implant Dent</stitle><date>2021-10-08</date><risdate>2021</risdate><volume>7</volume><issue>1</issue><spage>106</spage><epage>106</epage><pages>106-106</pages><artnum>106</artnum><issn>2198-4034</issn><eissn>2198-4034</eissn><abstract>Background
The incidence rate of peri-implant diseases is increasing with implant placement. Early detection of peri-implant diseases is important to prevent and treat these diseases, and a simple and objective diagnostic method is expected. Immunochromatographic (IC) assays are used for rapid diagnostic methods for some diseases. The aim of this clinical study was to determine the amount of calprotectin, an inflammatory marker, in peri-implant crevicular fluid (PICF) using an IC chip, and estimate the possibility of this diagnostic system.
Methods
Forty-six individuals with dental implants participated in a pilot study. PICF samples were collected from the peri-implant sites with or without inflammation after clinical examinations including probing depth (PD), bleeding on probing (BOP) and gingival index (GI). Calprotectin in PICF was determined by an IC chip and enzyme-linked immunosorbent assay (ELISA) for calprotectin. The density of calprotectin line on the IC chip was measured using an IC reader (IC reader value). The relationship between IC reader value and ELISA value or clinical parameters was investigated. A receiver operating characteristic (ROC) curve analysis of IC reader value of calprotectin was performed to predict inflammation in peri-implant diseases.
Results
IC reader value of calprotectin was significantly correlated with its ELISA value and PD. IC reader values of calprotectin in PICF samples from periodontal sites with GI-1 and GI-2, and with BOP-positive sites were significantly higher than those of PICF samples from GI-0 sites, and BOP-negative sites, respectively. The IC reader value for calprotectin in PICF samples from inflammatory diseased sites was significantly higher than that of non-diseased sites. ROC analysis suggested that the IC reader value of PICF calprotectin was useful for predicting inflammatory peri-implant diseases.
Conclusion
IC assay for PICF calprotectin may be a possible system for diagnosing the inflammatory peri-implant diseases.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34623545</pmid><doi>10.1186/s40729-021-00386-z</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-3949-5931</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Publicly Available Content Database; Springer Nature - SpringerLink Journals - Fully Open Access; PubMed Central; Coronavirus Research Database |
| subjects | Assaying Calprotectin Dental implants Dentistry Diagnosis Diagnostic systems Immunochromatographic assay Integrated circuits Medicine Peri-implant crevicular fluid Peri-implant diseases Transplants & implants |
| title | Diagnosis of inflammatory peri-implant diseases using an immunochromatographic assay for calprotectin in peri-implant crevicular fluid |
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